caa a22 4500 606221255 CHVBK 20210128101128.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00380-013-0434-y doi (NATIONALLICENCE)springer-10.1007/s00380-013-0434-y High incidence and severity of periodontitis in patients with Marfan syndrome in Japan [Elektronische Daten] [Jun-ichi Suzuki, Yasushi Imai, Mieko Aoki, Daishi Fujita, Norio Aoyama, Yuko Tada, Hiroshi Akazawa, Yuichi Izumi, Mitsuaki Isobe, Issei Komuro, Ryozo Nagai, Yasunobu Hirata] Marfan syndrome (MFS) is a systemic connective tissue disorder caused by mutations in the extracellular matrix protein fibrillin-1. While it is known that patients with MFS are at high risk of dental disorders and cardiovascular diseases, little information has been provided to date. To clarify the prevalence of periodontitis in patients with MFS, their oral condition and cardiovascular complications were evaluated. The subjects were patients with MFS (n = 40) who attended the University of Tokyo hospital; age- and gender-matched healthy individuals (n = 14) constituted a control group. Cardiovascular complications and full-mouth clinical measurements, including number of teeth, probing of pocket depth (PD), bleeding on probing (BOP), and community periodontal index (CPI) were recorded. MFS patients had more frequent cardiovascular complications (95 %) compared with the controls (0 %). MFS patients had periodontitis (CPI 3 and 4) more frequently (87.5 %) than the age- and gender-matched control subjects (35.7 %). Furthermore, MFS patients had significantly more severe periodontitis (CPI 2.90 ± 0.12 vs 1.64 ± 0.32) and fewer remaining teeth (26.7 ± 0.4 vs 28.4 ± 0.4) compared with the controls. However, PD and BOP were comparable between MFS patients and the control group. A high incidence of periodontitis and cardiovascular complications was observed in Japanese MFS patients. Springer Japan, 2013 Marfan syndrome nationallicence Cardiovascular complications nationallicence Periodontitis nationallicence Suzuki Jun-ichi Department of Advanced Clinical Science and Therapeutics, University of Tokyo, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut Imai Yasushi Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan aut Aoki Mieko Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan aut Fujita Daishi Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan aut Aoyama Norio Section of Periodontology, Department of Hard Tissue Engineering, Tokyo Medical and Dental University, Tokyo, Japan aut Tada Yuko Department of Advanced Clinical Science and Therapeutics, University of Tokyo, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut Akazawa Hiroshi Department of Advanced Clinical Science and Therapeutics, University of Tokyo, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut Izumi Yuichi Section of Periodontology, Department of Hard Tissue Engineering, Tokyo Medical and Dental University, Tokyo, Japan aut Isobe Mitsuaki Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan aut Komuro Issei Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan aut Nagai Ryozo Jichi Medical University, Shimotsuke, Japan aut Hirata Yasunobu Tokyo Teishin Hospital, Tokyo, Japan aut Heart and Vessels Springer Japan 30/5(2015-09-01), 692-695 0910-8327 30:5<692 2015 30 380 https://doi.org/10.1007/s00380-013-0434-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 brief-communication jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-013-0434-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suzuki Jun-ichi Department of Advanced Clinical Science and Therapeutics, University of Tokyo, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Imai Yasushi Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Aoki Mieko Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Fujita Daishi Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Aoyama Norio Section of Periodontology, Department of Hard Tissue Engineering, Tokyo Medical and Dental University, Tokyo, Japan aut NATIONALLICENCE 700 1- Tada Yuko Department of Advanced Clinical Science and Therapeutics, University of Tokyo, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Akazawa Hiroshi Department of Advanced Clinical Science and Therapeutics, University of Tokyo, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Izumi Yuichi Section of Periodontology, Department of Hard Tissue Engineering, Tokyo Medical and Dental University, Tokyo, Japan aut NATIONALLICENCE 700 1- Isobe Mitsuaki Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan aut NATIONALLICENCE 700 1- Komuro Issei Department of Cardiovascular Medicine, University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Nagai Ryozo Jichi Medical University, Shimotsuke, Japan aut NATIONALLICENCE 700 1- Hirata Yasunobu Tokyo Teishin Hospital, Tokyo, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/5(2015-09-01), 692-695 0910-8327 30:5<692 2015 30 380