caa a22 4500 606221263 CHVBK 20210128101128.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00380-014-0518-3 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0518-3 Autoimmunity and pulmonary hypertension in patients with Graves' disease [Elektronische Daten] [Tetsuro Sugiura, Shigeo Yamanaka, Hiroaki Takeuchi, Norihito Morimoto, Mikio Kamioka, Yoshihisa Matsumura] A link between hyperthyroidism and pulmonary hypertension has been reported, but the underlying mechanisms of these two conditions have not been clearly identified. The aim of this study was to determine the clinical correlates of pulmonary hypertension in patients with Graves' disease. Among 50 consecutive patients with Graves' disease referred for echocardiography, 18 patients (36%) had pulmonary hypertension measured by continuous-wave Doppler echocardiography (pulmonary artery systolic pressure >35mmHg). The patients with pulmonary hypertension had significantly higher pulmonary vascular resistance (PVR), cardiac output and thyroid-stimulating hormone receptor antibody (TRAb) compared to those without (p<0.001, p=0.028 and p<0.001, respectively). Pulmonary artery systolic pressure had a good correlation with TRAb (r=0.74, p<0.001), but was not related to free T4 (r=0.12, p=0.419) and free T3 (r=0.22, p=0.126). To determine the important variables present in patients with Graves' disease that may be related to pulmonary artery systolic pressure, 4 variables (PVR, cardiac output, TRAb and free T3) were used in the multivariate analysis. In addition to PVR (standard regression coefficient=0.831, p<0.001) and cardiac output (standard regression coefficient=0.592, p<0.001), TRAb (standard regression coefficient=0.178, p<0.001) emerged as a significant variable related to pulmonary artery systolic pressure. Thus, in addition to the effect of thyroid hormone on the cardiovascular system, autoimmune-mediated pulmonary vascular remodeling may play a role in Graves' disease-linked elevated pulmonary artery systolic pressure. The Author(s), 2014 Pulmonary hypertension nationallicence Hyperthyroidism nationallicence Echocardiography nationallicence Autoimmunity nationallicence Sugiura Tetsuro Department of Laboratory Medicine, Kochi Medical School, Kohasu Oko-cho, 783-8505, Nankoku City, Kochi, Japan aut Yamanaka Shigeo Department of Laboratory Medicine, Kochi Medical School, Kohasu Oko-cho, 783-8505, Nankoku City, Kochi, Japan aut Takeuchi Hiroaki Department of Laboratory Medicine, Kochi Medical School, Kohasu Oko-cho, 783-8505, Nankoku City, Kochi, Japan aut Morimoto Norihito Department of Laboratory Medicine, Kochi Medical School, Kohasu Oko-cho, 783-8505, Nankoku City, Kochi, Japan aut Kamioka Mikio Department of Laboratory Medicine, Kochi Medical School, Kohasu Oko-cho, 783-8505, Nankoku City, Kochi, Japan aut Matsumura Yoshihisa Department of Laboratory Medicine, Kochi Medical School, Kohasu Oko-cho, 783-8505, Nankoku City, Kochi, Japan aut Heart and Vessels Springer Japan 30/5(2015-09-01), 642-646 0910-8327 30:5<642 2015 30 380 https://doi.org/10.1007/s00380-014-0518-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0518-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sugiura Tetsuro Department of Laboratory Medicine, Kochi Medical School, Kohasu Oko-cho, 783-8505, Nankoku City, Kochi, Japan aut NATIONALLICENCE 700 1- Yamanaka Shigeo Department of Laboratory Medicine, Kochi Medical School, Kohasu Oko-cho, 783-8505, Nankoku City, Kochi, Japan aut NATIONALLICENCE 700 1- Takeuchi Hiroaki Department of Laboratory Medicine, Kochi Medical School, Kohasu Oko-cho, 783-8505, Nankoku City, Kochi, Japan aut NATIONALLICENCE 700 1- Morimoto Norihito Department of Laboratory Medicine, Kochi Medical School, Kohasu Oko-cho, 783-8505, Nankoku City, Kochi, Japan aut NATIONALLICENCE 700 1- Kamioka Mikio Department of Laboratory Medicine, Kochi Medical School, Kohasu Oko-cho, 783-8505, Nankoku City, Kochi, Japan aut NATIONALLICENCE 700 1- Matsumura Yoshihisa Department of Laboratory Medicine, Kochi Medical School, Kohasu Oko-cho, 783-8505, Nankoku City, Kochi, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/5(2015-09-01), 642-646 0910-8327 30:5<642 2015 30 380