caa a22 4500 606221271 CHVBK 20210128101128.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00380-014-0594-4 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0594-4 Efficacy and safety of novel epicardial circumferential left atrial ablation with pulmonary vein isolation in sustained atrial fibrillation [Elektronische Daten] [Zhaolei Jiang, Hang Yin, Yi He, Nan Ma, Min Tang, Hao Liu, Fangbao Ding, Ju Mei] The aim of this study was to examine the efficacy and safety of this novel epicardial circumferential left atrial ablation (CLAA) with pulmonary vein isolation (PVI) in sustained atrial fibrillation (AF). Thirty domestic pigs were divided equally into 3 groups: AF without ablation (AF group), AF with PVI (PVI group), and AF with CLAA and PVI (CLAA+PVI group). AF was induced by rapid atrial pacing. After AF was induced, CLAA and PVI were performed for pigs in CLAA+PVI group, and PVI was performed for pigs in PVI group. AF vulnerability, AF duration, and histology were performed in all groups. All pigs developed sustained AF after 6.27±0.69weeks of rapid atrial pacing. All pigs successfully underwent isolated PVI or CLAA with PVI on the beating heart in PVI group or CLAA+PVI group. Isolated PVI terminated AF in 3 of 20 pigs (15%), and CLAA with PVI terminated AF in 5 of 8 pigs (62.5%, P=0.022). Compared with AF group (10/10), the incidence of sustained AF by burst pacing was significantly decreased in PVI group (3/10, P=0.003) or CLAA+PVI group (0/10, P<0.001). There was no significant difference between PVI group and CLAA+PVI group (P=0.211). AF duration was significantly decreased in CLAA+PVI group (734.70±177.81s, 95% CI 607.51-861.89) compared with PVI group (1217.90±444.10s, 95% CI 900.21-1535.59, P=0.008). Also, AF duration was significantly decreased in PVI group (P=0.003) or CLAA+PVI group (P<0.001) in comparison with AF duration in AF group (average 1800s). Epicardial CLAA could ablate the left atrial roof and posterior wall together safely and reliably. Compared with PVI alone, CLAA with PVI may be able to improve the rate of acute termination of persistent AF. It may be useful in selecting the best ablation approaches for patients with persistent AF. Springer Japan, 2014 Atrial fibrillation nationallicence Ablation nationallicence Pulmonary vein isolation nationallicence Epicardial nationallicence Efficacy nationallicence Jiang Zhaolei Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092, Shanghai, China aut Yin Hang Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092, Shanghai, China aut He Yi Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092, Shanghai, China aut Ma Nan Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092, Shanghai, China aut Tang Min Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092, Shanghai, China aut Liu Hao Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092, Shanghai, China aut Ding Fangbao Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092, Shanghai, China aut Mei Ju Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092, Shanghai, China aut Heart and Vessels Springer Japan 30/5(2015-09-01), 675-681 0910-8327 30:5<675 2015 30 380 https://doi.org/10.1007/s00380-014-0594-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0594-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jiang Zhaolei Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092, Shanghai, China aut NATIONALLICENCE 700 1- Yin Hang Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092, Shanghai, China aut NATIONALLICENCE 700 1- He Yi Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092, Shanghai, China aut NATIONALLICENCE 700 1- Ma Nan Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092, Shanghai, China aut NATIONALLICENCE 700 1- Tang Min Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092, Shanghai, China aut NATIONALLICENCE 700 1- Liu Hao Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092, Shanghai, China aut NATIONALLICENCE 700 1- Ding Fangbao Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092, Shanghai, China aut NATIONALLICENCE 700 1- Mei Ju Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, 200092, Shanghai, China aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/5(2015-09-01), 675-681 0910-8327 30:5<675 2015 30 380