caa a22 4500 606221298 CHVBK 20210128101128.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00380-014-0529-0 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0529-0 Abnormal aortic arch morphology in Turner syndrome patients is a risk factor for hypertension [Elektronische Daten] [Katya De Groote, Daniël Devos, Koen Van Herck, Laurent Demulier, Wesley Buysse, Jean De Schepper, Daniël De Wolf] Hypertension in Turner syndrome (TS) is a multifactorial, highly prevalent and significant problem that warrants timely diagnosis and rigorous treatment. The objective of this study was to investigate the association between abnormal aortic arch morphology and hypertension in adult TS patients. This was a single centre retrospective study in 74 adult TS patients (age 29.41±8.91 years) who underwent a routine cardiac MRI. Patients were assigned to the hypertensive group (N=31) if blood pressure exceeded 140/90mmHg and/or if they were treated with antihypertensive medication. Aortic arch morphology was evaluated on MRI images and initially assigned as normal (N=54) or abnormal (N=20), based on the curve of the transverse arch and the distance between the left common carotid-left subclavian artery. We additionally used a new more objective method to describe aortic arch abnormality in TS by determination of the relative position of the highest point of the transverse arch (AoHP). Logistic regression analysis showed that hypertension is significantly and independently associated with age, BMI and abnormal arch morphology, with a larger effect size for the new AoHP method than for the classical method. TS patients with hypertension and abnormal arch morphology more often had dilatation of the ascending aorta. There is a significant association between abnormal arch morphology and hypertension in TS patients, independent of age and BMI, and not related to other structural heart disease. We suggest that aortic arch morphology should be included in the risk stratification for hypertension in TS and propose a new quantitative method to express aortic arch morphology. Springer Japan, 2014 Turner syndrome nationallicence Hypertension nationallicence Aortic arch nationallicence Ascending aorta nationallicence Risk stratification nationallicence De Groote Katya Division of Paediatric Cardiology, Department of Paediatrics, Ghent University Hospital, De Pintelaan 185, 3K12D, Administratie pediatrie, B-9000, Ghent, Belgium aut Devos Daniël Cardiovascular Magnetic Resonance, Department of Radiology, Ghent University Hospital, Ghent, Belgium aut Van Herck Koen Department of Public Health, Ghent University, Ghent, Belgium aut Demulier Laurent Department of Cardiology, Ghent University Hospital, Ghent, Belgium aut Buysse Wesley Department of Paediatrics, Ghent University Hospital, Ghent, Belgium aut De Schepper Jean Division of Paediatric Endocrinology, Department of Paediatrics, Ghent University Hospital, Ghent, Belgium aut De Wolf Daniël Division of Paediatric Cardiology, Department of Paediatrics, Ghent University Hospital, De Pintelaan 185, 3K12D, Administratie pediatrie, B-9000, Ghent, Belgium aut Heart and Vessels Springer Japan 30/5(2015-09-01), 618-625 0910-8327 30:5<618 2015 30 380 https://doi.org/10.1007/s00380-014-0529-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0529-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De Groote Katya Division of Paediatric Cardiology, Department of Paediatrics, Ghent University Hospital, De Pintelaan 185, 3K12D, Administratie pediatrie, B-9000, Ghent, Belgium aut NATIONALLICENCE 700 1- Devos Daniël Cardiovascular Magnetic Resonance, Department of Radiology, Ghent University Hospital, Ghent, Belgium aut NATIONALLICENCE 700 1- Van Herck Koen Department of Public Health, Ghent University, Ghent, Belgium aut NATIONALLICENCE 700 1- Demulier Laurent Department of Cardiology, Ghent University Hospital, Ghent, Belgium aut NATIONALLICENCE 700 1- Buysse Wesley Department of Paediatrics, Ghent University Hospital, Ghent, Belgium aut NATIONALLICENCE 700 1- De Schepper Jean Division of Paediatric Endocrinology, Department of Paediatrics, Ghent University Hospital, Ghent, Belgium aut NATIONALLICENCE 700 1- De Wolf Daniël Division of Paediatric Cardiology, Department of Paediatrics, Ghent University Hospital, De Pintelaan 185, 3K12D, Administratie pediatrie, B-9000, Ghent, Belgium aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/5(2015-09-01), 618-625 0910-8327 30:5<618 2015 30 380