caa a22 4500 606221301 CHVBK 20210128101128.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00380-014-0522-7 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0522-7 Impact of combined lipid lowering with blood pressure control on coronary plaque regression: rationale and design of MILLION study [Elektronische Daten] [Masa-aki Kawashiri, Kenji Sakata, Tadatsugu Gamou, Honin Kanaya, Kenji Miwa, Kosei Ueda, Toshinori Higashikata, Sumio Mizuno, Ichiro Michishita, Masanobu Namura, Yutaka Nitta, Shoji Katsuda, Kazuyasu Okeie, Hiroaki Hirase, Hayato Tada, Katsuharu Uchiyama, Tetsuo Konno, Kenshi Hayashi, Hidekazu Ino, Keisuke Nagase, Mitsuyasu Terashima, Masakazu Yamagishi] A line of epidemiological studies suggests that the accumulation of coronary risk factors promotes the progression of coronary atherosclerosis. Recent clinical studies showed that aggressive low-density lipoprotein (LDL) cholesterol-lowering therapy using statins could regress coronary atheroma and reduce major cardiovascular events. Additionally, therapy that controlled amlodipine-based blood pressure reduced major cardiovascular events in patients with hypertension compared with an atenolol-based regimen. An open-label randomized multicenter study is primarily planned to evaluate the changes in coronary atheroma volume using intravascular ultrasonography 18-24months after intensive lowering of LDL-cholesterol and blood pressure compared with a standard therapy indicated by current guidelines in Japanese patients with coronary artery disease (CAD). The secondary endpoints include changes in serum lipid levels, inflammatory markers, glucose markers and blood pressure. In total, 100 subjects with CAD who are undergoing percutaneous coronary intervention will be tested. The MILLION study will provide new evidence and therapeutic standards for the prevention of CAD in Japanese patients by controlling both LDL-C levels and blood pressure. Springer Japan, 2014 Amlodipine nationallicence Atorvastatin nationallicence Coronary plaque volume nationallicence Intravascular ultrasonography (IVUS) nationallicence Kawashiri Masa-aki Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut Sakata Kenji Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut Gamou Tadatsugu Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut Kanaya Honin Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan aut Miwa Kenji Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan aut Ueda Kosei Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan aut Higashikata Toshinori Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan aut Mizuno Sumio Department of Cardiology, Fukui Cardiovascular Center, Fukui, Japan aut Michishita Ichiro Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Yokohama, Japan aut Namura Masanobu Department of Cardiology, Kanazawa Cardiovascular Hospital, Kanazawa, Japan aut Nitta Yutaka Department of Cardiology, Toyama Red Cross Hospital, Toyama, Japan aut Katsuda Shoji Department of Cardiology, Toyama Red Cross Hospital, Toyama, Japan aut Okeie Kazuyasu Department of Cardiology, Koseiren Takaoka Hospital, Takaoka, Japan aut Hirase Hiroaki Department of Internal Medicine, Takaoka Municipal Hospital, Takaoka, Japan aut Tada Hayato Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut Uchiyama Katsuharu Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut Konno Tetsuo Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut Hayashi Kenshi Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut Ino Hidekazu Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut Nagase Keisuke Division of Medical Sciences, Kanazawa University Graduate School of Medicine, Kanazawa, Japan aut Terashima Mitsuyasu Cardiovascular Imaging Center, Toyohashi, Japan aut Yamagishi Masakazu Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut Heart and Vessels Springer Japan 30/5(2015-09-01), 580-586 0910-8327 30:5<580 2015 30 380 https://doi.org/10.1007/s00380-014-0522-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0522-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kawashiri Masa-aki Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 700 1- Sakata Kenji Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 700 1- Gamou Tadatsugu Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 700 1- Kanaya Honin Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan aut NATIONALLICENCE 700 1- Miwa Kenji Department of Cardiology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan aut NATIONALLICENCE 700 1- Ueda Kosei Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan aut NATIONALLICENCE 700 1- Higashikata Toshinori Department of Internal Medicine, Komatsu Municipal Hospital, Komatsu, Japan aut NATIONALLICENCE 700 1- Mizuno Sumio Department of Cardiology, Fukui Cardiovascular Center, Fukui, Japan aut NATIONALLICENCE 700 1- Michishita Ichiro Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, Yokohama, Japan aut NATIONALLICENCE 700 1- Namura Masanobu Department of Cardiology, Kanazawa Cardiovascular Hospital, Kanazawa, Japan aut NATIONALLICENCE 700 1- Nitta Yutaka Department of Cardiology, Toyama Red Cross Hospital, Toyama, Japan aut NATIONALLICENCE 700 1- Katsuda Shoji Department of Cardiology, Toyama Red Cross Hospital, Toyama, Japan aut NATIONALLICENCE 700 1- Okeie Kazuyasu Department of Cardiology, Koseiren Takaoka Hospital, Takaoka, Japan aut NATIONALLICENCE 700 1- Hirase Hiroaki Department of Internal Medicine, Takaoka Municipal Hospital, Takaoka, Japan aut NATIONALLICENCE 700 1- Tada Hayato Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 700 1- Uchiyama Katsuharu Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 700 1- Konno Tetsuo Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 700 1- Hayashi Kenshi Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 700 1- Ino Hidekazu Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 700 1- Nagase Keisuke Division of Medical Sciences, Kanazawa University Graduate School of Medicine, Kanazawa, Japan aut NATIONALLICENCE 700 1- Terashima Mitsuyasu Cardiovascular Imaging Center, Toyohashi, Japan aut NATIONALLICENCE 700 1- Yamagishi Masakazu Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medicine, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/5(2015-09-01), 580-586 0910-8327 30:5<580 2015 30 380