caa a22 4500 60622131X CHVBK 20210128101128.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00380-014-0533-4 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0533-4 Impact of advanced age on the severity of normotensive pulmonary embolism [Elektronische Daten] [Karsten Keller, Johannes Beule, Meike Coldewey, Wolfgang Dippold, Jörn Balzer] The prevalence of pulmonary embolism (PE) increases progressively with age. Less data about the impact of increasing age on the severity of PE are available. The objectives of this study were to investigate the impact of increasing age on the severity of normotensive PE. Retrospective analysis of clinical, laboratory, radiological and echocardiagraphic data of normotensive patients with PE was performed. According to patients' age at the moment of acute PE event, the total number of 129 normotensive PE patients was subdivided into 4 age groups. In age groups 18-59, 60-69, 70-79 and 80-94years were, respectively, a number of 30, 31, 33 and 35 patients included. Percentage of women in age groups increased with advanced age (P=0.021). Systolic pulmonary artery pressure (PAP) (P<0.0001) and frequency of incomplete or complete right bundle-branch block (RBBB) (P=0.019), of right ventricular dysfunction (RVD) (P=0.00031) and of submassive PE stadium with intermediate risk (P=0.0016) increased significantly with growing age. Multivariable regression model confirmed an association between age and submassive PE [OR (per year) 1.04; 95% CI, 1.02-1.07, P=0.0020] as well as female gender and submassive PE (OR 2.45; 95% CI, 1.10-5.50, P=0.029) and tachycardia and submassive PE (OR 15.33; 95% CI, 3.45-68.24, P=0.00034). Advanced age, female gender and tachycardia are risk factors for a submassive PE with intermediate risk in normotensive PE patients. The percentage of PE patients with submassive PE, right ventricular overload, RVD, RBBB, elevated systolic PAP increases with advanced age. Springer Japan, 2014 Pulmonary artery pressure nationallicence Submassive nationallicence Normotensive nationallicence Pulmonary embolism nationallicence Right ventricular dysfunction nationallicence Right ventricular failure nationallicence Age nationallicence Venous thromboembolism nationallicence AHA : American heart association nationallicence CT : Computed tomography nationallicence cTn : Cardiac troponin nationallicence cTnI : Cardiac troponin I nationallicence DVT : Deep vein thrombosis nationallicence ECG : Electrocardiography nationallicence ESC : European society of cardiology nationallicence PE : Pulmonary embolism nationallicence RBBB : Right bundle-branch block nationallicence RVD : Right ventricular dysfunction nationallicence SD : Standard deviation nationallicence PAP : Systolic pulmonary artery pressure nationallicence PESI : Pulmonary embolism severity index nationallicence V/Q scan : Ventilation-perfusion scan nationallicence VTE : Venous thromboembolism nationallicence Keller Karsten Department of Medicine II, University Medical Center Mainz, Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany aut Beule Johannes Department of Internal Medicine, St. Vincenz and Elisabeth Hospital Mainz (KKM), Mainz, Germany aut Coldewey Meike Department of Medicine II, University Medical Center Mainz, Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany aut Dippold Wolfgang Department of Internal Medicine, St. Vincenz and Elisabeth Hospital Mainz (KKM), Mainz, Germany aut Balzer Jörn Department of Radiology and Nuclear Medicine, Catholic Clinic Mainz (KKM), Mainz, Germany aut Heart and Vessels Springer Japan 30/5(2015-09-01), 647-656 0910-8327 30:5<647 2015 30 380 https://doi.org/10.1007/s00380-014-0533-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0533-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Keller Karsten Department of Medicine II, University Medical Center Mainz, Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany aut NATIONALLICENCE 700 1- Beule Johannes Department of Internal Medicine, St. Vincenz and Elisabeth Hospital Mainz (KKM), Mainz, Germany aut NATIONALLICENCE 700 1- Coldewey Meike Department of Medicine II, University Medical Center Mainz, Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany aut NATIONALLICENCE 700 1- Dippold Wolfgang Department of Internal Medicine, St. Vincenz and Elisabeth Hospital Mainz (KKM), Mainz, Germany aut NATIONALLICENCE 700 1- Balzer Jörn Department of Radiology and Nuclear Medicine, Catholic Clinic Mainz (KKM), Mainz, Germany aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/5(2015-09-01), 647-656 0910-8327 30:5<647 2015 30 380