caa a22 4500 606221336 CHVBK 20210128101128.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00380-014-0509-4 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0509-4 Dipeptidyl peptidase-4 inhibitors are associated with improved left ventricular diastolic function after acute myocardial infarction in diabetic patients [Elektronische Daten] [Takayuki Fujiwara, Masashi Yoshida, Tomohiro Nakamura, Kenichi Sakakura, Hiroshi Wada, Kenshiro Arao, Takuji Katayama, Hiroshi Funayama, Yoshitaka Sugawara, Takeshi Mitsuhashi, Masafumi Kakei, Shin-ichi Momomura, Junya Ako] Dipeptidyl peptidase-4 (DPP4) is an integral membrane glycoprotein that modulates the pathological state of diabetes mellitus (DM), and DPP4 inhibitors are a new class of anti-type-2 DM drugs. Recent preclinical studies have associated DPP4 inhibition with improved myocardial systolic and diastolic function. Based on preclinical findings, we investigated associations between the administration of DPP4 inhibitors and cardiac function after acute myocardial infarction (AMI) in a clinical setting. We enrolled 34 patients with diabetes who were treated for acute myocardial infarction at our hospital between January 2010 and December 2012. We retrospectively compared changes in cardiac parameters determined by trans-thoracic echocardiography between patients treated with (DPP4-I group; n=13) or without (non-DPP4-I group; n=21) a DPP4 inhibitor during follow-up. The values of E/e′ and of e′/a′ significantly decreased and increased, respectively, in the DPP4-I, compared with the non-DPP4-I group (−2.53±5.53 vs. 2.58±5.68, p=0.038 and 0.08±0.23 vs. −0.12±0.21, p=0.036, respectively). We concluded that DPP4 inhibitors could improve E/e′ and e′/a′ in patients with DM and AMI and thus might be effective for treating left ventricular diastolic failure. Springer Japan, 2014 Dipeptidyl peptidase-4 inhibitor nationallicence Diastolic function nationallicence Diabetes mellitus nationallicence Acute myocardial infarction nationallicence Fujiwara Takayuki Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Yoshida Masashi Department of Endocrinology and Metabolism, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Nakamura Tomohiro Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Sakakura Kenichi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Wada Hiroshi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Arao Kenshiro Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Katayama Takuji Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Funayama Hiroshi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Sugawara Yoshitaka Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Mitsuhashi Takeshi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Kakei Masafumi Department of Endocrinology and Metabolism, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Momomura Shin-ichi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut Ako Junya Department of Cardiovascular Medicine, Kitasato University, 1-15-1 Kitasato, Minami Ward, 252-0375, Sagamihara, Kanagawa, Japan aut Heart and Vessels Springer Japan 30/5(2015-09-01), 696-701 0910-8327 30:5<696 2015 30 380 https://doi.org/10.1007/s00380-014-0509-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 brief-communication jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0509-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fujiwara Takayuki Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Yoshida Masashi Department of Endocrinology and Metabolism, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Nakamura Tomohiro Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Sakakura Kenichi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Wada Hiroshi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Arao Kenshiro Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Katayama Takuji Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Funayama Hiroshi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Sugawara Yoshitaka Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Mitsuhashi Takeshi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Kakei Masafumi Department of Endocrinology and Metabolism, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Momomura Shin-ichi Department of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya Ward, 330-8503, Saitama, Saitama, Japan aut NATIONALLICENCE 700 1- Ako Junya Department of Cardiovascular Medicine, Kitasato University, 1-15-1 Kitasato, Minami Ward, 252-0375, Sagamihara, Kanagawa, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/5(2015-09-01), 696-701 0910-8327 30:5<696 2015 30 380