caa a22 4500 606221387 CHVBK 20210128101128.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00380-014-0516-5 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0516-5 Lack of association between peri-procedural myocardial damage and CYP2C19 gene variant in elective percutaneous coronary intervention [Elektronische Daten] [Hiromi Yoshimura, Koichi Kaikita, Takamichi Ono, Satomi Iwashita, Naoki Nakayama, Koji Sato, Eiji Horio, Kenichi Tsujita, Sunao Kojima, Shinji Tayama, Seiji Hokimoto, Hisao Ogawa] Peri-procedural myocardial damage (MD) is associated with increased risk of major in-hospital complications and adverse clinical events. The aim of this study was to evaluate the effects of on-clopidogrel platelet aggregation and CYP2C19-reduced-function gene variants on elective percutaneous coronary intervention (PCI)-related MD. We measured changes in serum high-sensitive troponin T (hs-TnT) levels, CYP2C19 genotype, and on-clopidogrel platelet aggregation (PA) using VerifyNow® P2Y12 system in 91 patients who received stent implantation (stent group). The control group comprised 30 patients who did not receive PCI. Blood samples were obtained before and 24h after PCI or coronary angiography (CAG). Patients of the stent group were divided into high and low MD groups based on the median value of hs-TnT level at 24h after PCI. Serum hs-TnT levels were significantly higher 24h after PCI (86.8±121.5pg/ml) compared with before PCI (9.4±5.3, p<0.001), whereas the levels were identical before and 24h after CAG in the control group. Simple logistic regression analysis demonstrated that MD correlated with age (p=0.014), estimated GFR (p=0.003), hemoglobin A1c (p=0.015), baseline serum hs-TnT (p=0.049), and stent length (p<0.001). Multiple logistic regression analysis identified old age, high hemoglobin A1c level, and long stent, but not CYP2C19 reduced-function allele or high on-clopidogrel PA, as independent predictors of elective PCI-related MD. The present study demonstrated no significant relation between peri-procedural MD and high on-clopidgrel PA associated with CYP2C19 reduced-function allele in patients undergoing elective PCI. Springer Japan, 2014 Angina pectoris nationallicence Coronary artery disease nationallicence Blood coagulation nationallicence Platelets nationallicence Thrombosis nationallicence Yoshimura Hiromi Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut Kaikita Koichi Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut Ono Takamichi Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut Iwashita Satomi Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut Nakayama Naoki Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut Sato Koji Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut Horio Eiji Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut Tsujita Kenichi Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut Kojima Sunao Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut Tayama Shinji Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut Hokimoto Seiji Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut Ogawa Hisao Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut Heart and Vessels Springer Japan 30/5(2015-09-01), 572-579 0910-8327 30:5<572 2015 30 380 https://doi.org/10.1007/s00380-014-0516-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0516-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoshimura Hiromi Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Kaikita Koichi Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Ono Takamichi Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Iwashita Satomi Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Nakayama Naoki Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Sato Koji Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Horio Eiji Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Tsujita Kenichi Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Kojima Sunao Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Tayama Shinji Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Hokimoto Seiji Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 700 1- Ogawa Hisao Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, 860-8556, Kumamoto, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/5(2015-09-01), 572-579 0910-8327 30:5<572 2015 30 380