caa a22 4500 606221395 CHVBK 20210128101128.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00380-014-0564-x doi (NATIONALLICENCE)springer-10.1007/s00380-014-0564-x Myocardial protection of early extracorporeal membrane oxygenation (ECMO) support for acute myocardial infarction with cardiogenic shock in pigs [Elektronische Daten] [Gang-jie Zhu, Li-na Sun, Xing-hai Li, Ning-fu Wang, Hong-hai Wu, Chen-xing Yuan, Qiao-qiao Li, Peng Xu, Ya-qi Ren, Bao-gen Mao] The aim of this study was to explore myocardial protection of early extracorporeal membrane oxygenation (ECMO) support for acute myocardial infarction with cardiogenic shock in pigs. 24 male pigs (34.6±1.3kg) were randomly divided into three groups—control group, drug therapy group, and ECMO group. Myocardial infarction model was created in drug therapy group and ECMO group by ligating coronary artery. When cardiogenic shock occurred, drugs were given in drug therapy group and ECMO began to work in ECMO group. The pigs were killed 24h after cardiogenic shock. Compared with in drug therapy group, left ventricular end-diastolic pressure in ECMO group decreased significantly 6h after ligation (P<0.05). At the end of the experiments, LV−dp/dt among three groups was significantly different, drug therapy group<ECMO group<control group. There was no difference in LV+dp/dt between drug therapy group and ECMO group. Compared with drug group, myocardial infarct size of ECMO group did not reduce significantly, but myocardial enzyme and troponin-I decreased significantly. Compared with drug therapy, ECMO improves left ventricular diastolic function, and may improve systolic function. ECMO cannot reduce myocardial infarct size without revascularization, but may have positive effects on ischemic areas by avoiding further injuring. Springer Japan, 2014 Myocardial protection nationallicence Extracorporeal membrane oxygenation (ECMO) nationallicence Acute myocardial infarction nationallicence Cardiogenic shock nationallicence Pigs nationallicence Zhu Gang-jie Department of Cardiovasology, Affiliated Hangzhou Hospital of Nanjing Medical University, No.261, Huansha Road, 310006, Hangzhou City, China aut Sun Li-na Department of Cardiovasology, Affiliated Hangzhou Hospital of Nanjing Medical University, No.261, Huansha Road, 310006, Hangzhou City, China aut Li Xing-hai Department of Cardiac Surgery, Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou City, China aut Wang Ning-fu Department of Cardiovasology, Affiliated Hangzhou Hospital of Nanjing Medical University, No.261, Huansha Road, 310006, Hangzhou City, China aut Wu Hong-hai Zhejiang University, Hangzhou City, China aut Yuan Chen-xing Zhejiang University, Hangzhou City, China aut Li Qiao-qiao Zhejiang University, Hangzhou City, China aut Xu Peng Department of Cardiovasology, Affiliated Hangzhou Hospital of Nanjing Medical University, No.261, Huansha Road, 310006, Hangzhou City, China aut Ren Ya-qi Department of Cardiovasology, Affiliated Hangzhou Hospital of Nanjing Medical University, No.261, Huansha Road, 310006, Hangzhou City, China aut Mao Bao-gen Department of Cardiac Surgery, Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou City, China aut Heart and Vessels Springer Japan 30/5(2015-09-01), 669-674 0910-8327 30:5<669 2015 30 380 https://doi.org/10.1007/s00380-014-0564-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0564-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhu Gang-jie Department of Cardiovasology, Affiliated Hangzhou Hospital of Nanjing Medical University, No.261, Huansha Road, 310006, Hangzhou City, China aut NATIONALLICENCE 700 1- Sun Li-na Department of Cardiovasology, Affiliated Hangzhou Hospital of Nanjing Medical University, No.261, Huansha Road, 310006, Hangzhou City, China aut NATIONALLICENCE 700 1- Li Xing-hai Department of Cardiac Surgery, Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou City, China aut NATIONALLICENCE 700 1- Wang Ning-fu Department of Cardiovasology, Affiliated Hangzhou Hospital of Nanjing Medical University, No.261, Huansha Road, 310006, Hangzhou City, China aut NATIONALLICENCE 700 1- Wu Hong-hai Zhejiang University, Hangzhou City, China aut NATIONALLICENCE 700 1- Yuan Chen-xing Zhejiang University, Hangzhou City, China aut NATIONALLICENCE 700 1- Li Qiao-qiao Zhejiang University, Hangzhou City, China aut NATIONALLICENCE 700 1- Xu Peng Department of Cardiovasology, Affiliated Hangzhou Hospital of Nanjing Medical University, No.261, Huansha Road, 310006, Hangzhou City, China aut NATIONALLICENCE 700 1- Ren Ya-qi Department of Cardiovasology, Affiliated Hangzhou Hospital of Nanjing Medical University, No.261, Huansha Road, 310006, Hangzhou City, China aut NATIONALLICENCE 700 1- Mao Bao-gen Department of Cardiac Surgery, Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou City, China aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/5(2015-09-01), 669-674 0910-8327 30:5<669 2015 30 380