caa a22 4500 606221417 CHVBK 20210128101128.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00380-014-0530-7 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0530-7 A high-risk patient with long-QT syndrome with no response to cardioselective beta-blockers [Elektronische Daten] [Naoki Toyota, Aya Miyazaki, Heima Sakaguchi, Wataru Shimizu, Hideo Ohuchi] We present a case of a high-risk 19-year-old female with long-QT syndrome (LQTS) with compound mutations. She had a history of aborted cardiac arrest and syncope and had received treatment with propranolol for 15years. However, because she developed adult-onset asthma we tried to switch propranolol, a nonselective beta-blocker, to beta-1-cardioselective agents, bisoprolol and metoprolol. These resulted in both a markedly prolonged corrected QT interval and the development of LQTS-associated arrhythmias. Eventually, propranolol was reinitiated at a higher dose with the addition of verapamil, and she has had no further cardiac or asthmatic events for 5years. Springer Japan, 2014 Long-QT syndrome nationallicence High-risk patient nationallicence Beta-blocker nationallicence Nonselective beta-blocker nationallicence Beta-1 selective blocker nationallicence Toyota Naoki Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan aut Miyazaki Aya Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan aut Sakaguchi Heima Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan aut Shimizu Wataru Department of Cardiovascular Medicine, Division of Arrhythmias and Electrophysiology, National Cerebral and Cardiovascular Center, Osaka, Japan aut Ohuchi Hideo Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan aut Heart and Vessels Springer Japan 30/5(2015-09-01), 687-691 0910-8327 30:5<687 2015 30 380 https://doi.org/10.1007/s00380-014-0530-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0530-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Toyota Naoki Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan aut NATIONALLICENCE 700 1- Miyazaki Aya Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan aut NATIONALLICENCE 700 1- Sakaguchi Heima Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan aut NATIONALLICENCE 700 1- Shimizu Wataru Department of Cardiovascular Medicine, Division of Arrhythmias and Electrophysiology, National Cerebral and Cardiovascular Center, Osaka, Japan aut NATIONALLICENCE 700 1- Ohuchi Hideo Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/5(2015-09-01), 687-691 0910-8327 30:5<687 2015 30 380