caa a22 4500 606221425 CHVBK 20210128101129.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00380-014-0515-6 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0515-6 Development of new risk score for pre-test probability of obstructive coronary artery disease based on coronary CT angiography [Elektronische Daten] [Shinichiro Fujimoto, Takeshi Kondo, Hideya Yamamoto, Naoyuki Yokoyama, Yasuhiro Tarutani, Kazuhisa Takamura, Yoji Urabe, Kumiko Konno, Yuji Nishizaki, Tomohiro Shinozaki, Yasuki Kihara, Hiroyuki Daida, Takaaki Isshiki, Shinichi Takase] Existing methods to calculate pre-test probability of obstructive coronary artery disease (CAD) have been established using selected high-risk patients who were referred to conventional coronary angiography. The purpose of this study is to develop and validate our new method for pre-test probability of obstructive CAD using patients who underwent coronary CT angiography (CTA), which could be applicable to a wider range of patient population. Using consecutive 4137 patients with suspected CAD who underwent coronary CTA at our institution, a multivariate logistic regression model including clinical factors as covariates calculated the pre-test probability (K-score) of obstructive CAD determined by coronary CTA. The K-score was compared with the Duke clinical score using the area under the curve (AUC) for the receiver-operating characteristic curve. External validation was performed by an independent sample of 319 patients. The final model included eight significant predictors: age, gender, coronary risk factor (hypertension, diabetes mellitus, dyslipidemia, smoking), history of cerebral infarction, and chest symptom. The AUC of the K-score was significantly greater than that of the Duke clinical score for both derivation (0.736 vs. 0.699) and validation (0.714 vs. 0.688) data sets. Among patients who underwent coronary CTA, newly developed K-score had better pre-test prediction ability of obstructive CAD compared to Duke clinical score in Japanese population. Springer Japan, 2014 Obstructive coronary artery disease nationallicence Coronary computed tomography angiography nationallicence Pre-test probability nationallicence Duke clinical score nationallicence New score nationallicence Fujimoto Shinichiro Department of Cardiology, Takase Clinic, Takasaki, Japan aut Kondo Takeshi Department of Cardiology, Takase Clinic, Takasaki, Japan aut Yamamoto Hideya Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan aut Yokoyama Naoyuki Division of Cardiology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan aut Tarutani Yasuhiro Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan aut Takamura Kazuhisa Department of Cardiology, Takase Clinic, Takasaki, Japan aut Urabe Yoji Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan aut Konno Kumiko Division of Cardiology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan aut Nishizaki Yuji Department of Cardiology, Juntendo University Graduate School of Medicine, 113-8421, Tokyo, Japan aut Shinozaki Tomohiro Department of Biostatistics, The University of Tokyo, School of Public Health, Tokyo, Japan aut Kihara Yasuki Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan aut Daida Hiroyuki Department of Cardiology, Juntendo University Graduate School of Medicine, 113-8421, Tokyo, Japan aut Isshiki Takaaki Division of Cardiology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan aut Takase Shinichi Department of Cardiology, Takase Clinic, Takasaki, Japan aut Heart and Vessels Springer Japan 30/5(2015-09-01), 563-571 0910-8327 30:5<563 2015 30 380 https://doi.org/10.1007/s00380-014-0515-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0515-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fujimoto Shinichiro Department of Cardiology, Takase Clinic, Takasaki, Japan aut NATIONALLICENCE 700 1- Kondo Takeshi Department of Cardiology, Takase Clinic, Takasaki, Japan aut NATIONALLICENCE 700 1- Yamamoto Hideya Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan aut NATIONALLICENCE 700 1- Yokoyama Naoyuki Division of Cardiology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Tarutani Yasuhiro Department of Cardiology, Okamura Memorial Hospital, Shizuoka, Japan aut NATIONALLICENCE 700 1- Takamura Kazuhisa Department of Cardiology, Takase Clinic, Takasaki, Japan aut NATIONALLICENCE 700 1- Urabe Yoji Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan aut NATIONALLICENCE 700 1- Konno Kumiko Division of Cardiology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Nishizaki Yuji Department of Cardiology, Juntendo University Graduate School of Medicine, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Shinozaki Tomohiro Department of Biostatistics, The University of Tokyo, School of Public Health, Tokyo, Japan aut NATIONALLICENCE 700 1- Kihara Yasuki Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan aut NATIONALLICENCE 700 1- Daida Hiroyuki Department of Cardiology, Juntendo University Graduate School of Medicine, 113-8421, Tokyo, Japan aut NATIONALLICENCE 700 1- Isshiki Takaaki Division of Cardiology, Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Takase Shinichi Department of Cardiology, Takase Clinic, Takasaki, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/5(2015-09-01), 563-571 0910-8327 30:5<563 2015 30 380