caa a22 4500 606221476 CHVBK 20210128101129.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00380-013-0455-6 doi (NATIONALLICENCE)springer-10.1007/s00380-013-0455-6 Ventricular arrhythmias induced by long-term use of ephedrine in two competitive athletes [Elektronische Daten] [Michela Casella, Antonio Dello Russo, Gennaro Izzo, Maurizio Pieroni, Daniele Andreini, Eleonora Russo, Daniele Colombo, Fabrizio Bologna, Leonardo Bolognese, Paolo Zeppilli, Claudio Tondo] Ephedrine is a sympathomimetic substance used by sportsmen as a doping substance because of its stimulating and slimming effects. We report two cases of ventricular arrhythmias induced by abuse of ephedrine in two competitive athletes. Endomyocardial biopsies guided by electroanatomic mapping revealed contraction-band necrosis, a myocardial injury frequently observed in cases of catecholamine excess. Our cases suggest that long-term abuse of ephedrine may result in myocardial damage, and that these structural alterations may promote areas of slow conduction favoring re-entrant ventricular tachyarrhythmias and a long-lasting risk of ventricular arrhythmias. Springer Japan, 2014 Ventricular arrhythmia nationallicence Endomyocardial biopsy nationallicence Electroanatomic mapping nationallicence Casella Michela Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino, IRCCS, Via Parea, 4, 20138, Milan, Italy aut Dello Russo Antonio Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino, IRCCS, Via Parea, 4, 20138, Milan, Italy aut Izzo Gennaro Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino, IRCCS, Via Parea, 4, 20138, Milan, Italy aut Pieroni Maurizio Cardiovascular Department, San Donato Hospital, Arezzo, Italy aut Andreini Daniele Department of Cardiovascular Imaging, Cardiac Arrhythmia Centre Centro Cardiologico Monzino, IRCCS, Milan, Italy aut Russo Eleonora Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino, IRCCS, Via Parea, 4, 20138, Milan, Italy aut Colombo Daniele Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino, IRCCS, Via Parea, 4, 20138, Milan, Italy aut Bologna Fabrizio Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino, IRCCS, Via Parea, 4, 20138, Milan, Italy aut Bolognese Leonardo Cardiovascular Department, San Donato Hospital, Arezzo, Italy aut Zeppilli Paolo Department of Sports Medicine, Catholic University of the Sacred Heart, Rome, Italy aut Tondo Claudio Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino, IRCCS, Via Parea, 4, 20138, Milan, Italy aut Heart and Vessels Springer Japan 30/2(2015-03-01), 280-283 0910-8327 30:2<280 2015 30 380 https://doi.org/10.1007/s00380-013-0455-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-013-0455-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Casella Michela Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino, IRCCS, Via Parea, 4, 20138, Milan, Italy aut NATIONALLICENCE 700 1- Dello Russo Antonio Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino, IRCCS, Via Parea, 4, 20138, Milan, Italy aut NATIONALLICENCE 700 1- Izzo Gennaro Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino, IRCCS, Via Parea, 4, 20138, Milan, Italy aut NATIONALLICENCE 700 1- Pieroni Maurizio Cardiovascular Department, San Donato Hospital, Arezzo, Italy aut NATIONALLICENCE 700 1- Andreini Daniele Department of Cardiovascular Imaging, Cardiac Arrhythmia Centre Centro Cardiologico Monzino, IRCCS, Milan, Italy aut NATIONALLICENCE 700 1- Russo Eleonora Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino, IRCCS, Via Parea, 4, 20138, Milan, Italy aut NATIONALLICENCE 700 1- Colombo Daniele Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino, IRCCS, Via Parea, 4, 20138, Milan, Italy aut NATIONALLICENCE 700 1- Bologna Fabrizio Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino, IRCCS, Via Parea, 4, 20138, Milan, Italy aut NATIONALLICENCE 700 1- Bolognese Leonardo Cardiovascular Department, San Donato Hospital, Arezzo, Italy aut NATIONALLICENCE 700 1- Zeppilli Paolo Department of Sports Medicine, Catholic University of the Sacred Heart, Rome, Italy aut NATIONALLICENCE 700 1- Tondo Claudio Cardiac Arrhythmia Research Centre, Centro Cardiologico Monzino, IRCCS, Via Parea, 4, 20138, Milan, Italy aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/2(2015-03-01), 280-283 0910-8327 30:2<280 2015 30 380