caa a22 4500 606221492 CHVBK 20210128101129.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00380-014-0468-9 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0468-9 Remodeling pattern is related to the degree of coronary plaque regression induced by pitavastatin: a sub-analysis of the TOGETHAR trial with intravascular ultrasound and coronary angioscopy [Elektronische Daten] [Tadateru Takayama, Takafumi Hiro, Yasunori Ueda, Satoshi Saito, Kazuhisa Kodama, Sei Komatsu, Atsushi Hirayama] This study aimed to clarify the relationships between arterial remodeling patterns and plaque volume regression or stabilization. The TOGETHAR trial is a prospective open-label trial designed to assess coronary plaque regression and stabilization with multiple plaque imaging modalities following 52weeks of pitavastatin treatment (2mg/day). Coronary plaques were observed in 46 patients with both angioscopy and intravascular ultrasound at baseline and after 52weeks of drug treatment. We divided these patients into three groups according to their remodeling indices (RI). Group P consisted of patients with a baseline RI >1.05, Group M of patients with a baseline RI of 0.95-1.05, and Group N of patients with a baseline RI <0.95 and then evaluated differences in coronary plaque volume changes and yellow grade among the three groups. In the positive remodeling group, whose remodeling index (RI) exceeded 1.05 at baseline, RI and percent atheroma volume (PAV) were significantly reduced (RI 1.14±0.07 to 1.05±0.10, p=0.010, PAV 47.3±8.3 to 45.3±7.3mm3, p=0.048). There was no relationship between baseline RI and the change in yellow grade of plaque. RI increased without significant change of PAV or a decrease in lumen volume in group N, with RI below 0.95 at baseline. Plaques with positive remodeling were more likely to have plaque volume regression by pitavastatin than those without in patients with coronary artery disease. Moreover, plaques with positive and negative remodeling were changed into those with intermediate remodeling by pitavastatin. Pitavastatin might induce not only plaque regression or stabilization, but also conformational normalization of vessel structure. Springer Japan, 2014 Pitavastatin nationallicence Angioscopy nationallicence Intravascular ultrasound nationallicence Arterial remodeling nationallicence Plaque regression nationallicence Takayama Tadateru Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Ohyaguchi-kamicho, Itabashi-ku, 173-8610, Tokyo, Japan aut Hiro Takafumi Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Ohyaguchi-kamicho, Itabashi-ku, 173-8610, Tokyo, Japan aut Ueda Yasunori Division of Cardiovascular Medicine, Keiai Hospital, Tokyo, Japan aut Saito Satoshi Cardiovascular Division, Osaka Police Hospital, Osaka, Japan aut Kodama Kazuhisa Cardiovascular Center, Amagasaki Central Hospital, Hyogo, Japan aut Komatsu Sei Cardiovascular Center, Amagasaki Central Hospital, Hyogo, Japan aut Hirayama Atsushi Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Ohyaguchi-kamicho, Itabashi-ku, 173-8610, Tokyo, Japan aut Heart and Vessels Springer Japan 30/2(2015-03-01), 169-176 0910-8327 30:2<169 2015 30 380 https://doi.org/10.1007/s00380-014-0468-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0468-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takayama Tadateru Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Ohyaguchi-kamicho, Itabashi-ku, 173-8610, Tokyo, Japan aut NATIONALLICENCE 700 1- Hiro Takafumi Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Ohyaguchi-kamicho, Itabashi-ku, 173-8610, Tokyo, Japan aut NATIONALLICENCE 700 1- Ueda Yasunori Division of Cardiovascular Medicine, Keiai Hospital, Tokyo, Japan aut NATIONALLICENCE 700 1- Saito Satoshi Cardiovascular Division, Osaka Police Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Kodama Kazuhisa Cardiovascular Center, Amagasaki Central Hospital, Hyogo, Japan aut NATIONALLICENCE 700 1- Komatsu Sei Cardiovascular Center, Amagasaki Central Hospital, Hyogo, Japan aut NATIONALLICENCE 700 1- Hirayama Atsushi Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Ohyaguchi-kamicho, Itabashi-ku, 173-8610, Tokyo, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/2(2015-03-01), 169-176 0910-8327 30:2<169 2015 30 380