caa a22 4500 606221549 CHVBK 20210128101129.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00380-013-0466-3 doi (NATIONALLICENCE)springer-10.1007/s00380-013-0466-3 High HDL cholesterol level after treatment with pitavastatin is an important factor for regression in carotid intima-media thickness [Elektronische Daten] [Kenji Okumura, Hideto Tsukamoto, Hideyuki Tsuboi, Haruo Hirayama, Haruo Kamiya, Masato Watarai, Ryoji Ishiki, Toyoaki Murohara] This study is a prospective multicenter study designed to investigate the effects of lipid-lowering therapy with pitavastatin on atherosclerotic plaque in patients with coronary heart disease, and to determine which factor is more closely associated with plaque regression. Participants (n=63) were treated with pitavastatin for 12months, and the carotid intima-media thickness (IMT) was measured by ultrasound before and after treatment. Mean IMT slightly but significantly decreased (from 0.99±0.33 to 0.94±0.28mm for overall, P=0.01) regardless of the presence of pretreatment with other statins. There were no significant relations with hs-CRP, malondialdehyde-LDL, LDL cholesterol, and smaller LDL cholesterol levels despite their decrease by pitavastatin. Decreases in mean IMT were observed significantly more frequently in subjects with high on-treatment HDL cholesterol levels than with low HDL cholesterol levels (P=0.017). The change in mean IMT tended to be inversely correlated with increments in HDL cholesterol and apolipoprotein A-I. The IMT regression was more often observed in the absence of diabetes and metabolic syndrome. In conclusion, we demonstrated that treatment with pitavastatin attenuated atherosclerotic plaque. This effect was associated with the level of HDL cholesterol, and was stronger in the absence of diabetes and metabolic syndrome in our ischemic heart disease patients. Springer Japan, 2014 Intima-media thickness nationallicence Pitavastatin nationallicence HDL cholesterol nationallicence Lipoproteins nationallicence Okumura Kenji Department of Cardiology, Toki Municipal General Hospital, 703-24 Tokiguchi, Tokitsu-cho, 509-5193, Toki, Gifu, Japan aut Tsukamoto Hideto Department of Cardiology, Toki Municipal General Hospital, 703-24 Tokiguchi, Tokitsu-cho, 509-5193, Toki, Gifu, Japan aut Tsuboi Hideyuki Department of Cardiology, Ogaki Municipal Hospital, Ogaki, Japan aut Hirayama Haruo Department of Cardiology, Nagoya Daini Red Cross Hospital, Nagoya, Japan aut Kamiya Haruo Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan aut Watarai Masato Cardiovascular Center, Anjo Kosei Hospital, Anjo, Japan aut Ishiki Ryoji Department of Internal Medicine, Toyota Memorial Hospital, Toyota, Japan aut Murohara Toyoaki Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan aut Heart and Vessels Springer Japan 30/2(2015-03-01), 154-161 0910-8327 30:2<154 2015 30 380 https://doi.org/10.1007/s00380-013-0466-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-013-0466-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Okumura Kenji Department of Cardiology, Toki Municipal General Hospital, 703-24 Tokiguchi, Tokitsu-cho, 509-5193, Toki, Gifu, Japan aut NATIONALLICENCE 700 1- Tsukamoto Hideto Department of Cardiology, Toki Municipal General Hospital, 703-24 Tokiguchi, Tokitsu-cho, 509-5193, Toki, Gifu, Japan aut NATIONALLICENCE 700 1- Tsuboi Hideyuki Department of Cardiology, Ogaki Municipal Hospital, Ogaki, Japan aut NATIONALLICENCE 700 1- Hirayama Haruo Department of Cardiology, Nagoya Daini Red Cross Hospital, Nagoya, Japan aut NATIONALLICENCE 700 1- Kamiya Haruo Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan aut NATIONALLICENCE 700 1- Watarai Masato Cardiovascular Center, Anjo Kosei Hospital, Anjo, Japan aut NATIONALLICENCE 700 1- Ishiki Ryoji Department of Internal Medicine, Toyota Memorial Hospital, Toyota, Japan aut NATIONALLICENCE 700 1- Murohara Toyoaki Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/2(2015-03-01), 154-161 0910-8327 30:2<154 2015 30 380