caa a22 4500 60622159X CHVBK 20210128101129.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00380-014-0469-8 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0469-8 Serum cholinesterase is an important prognostic factor in chronic heart failure [Elektronische Daten] [Takamasa Sato, Hiroyuki Yamauchi, Satoshi Suzuki, Akiomi Yoshihisa, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika Takeishi] We determine the importance of indicators of nutrition including lymphocyte, total protein, albumin, cholinesterase and body mass index, and compare the prognostic significance in chronic heart failure (CHF). We examined consecutive 465 CHF patients (376 males, age 62±14years) who underwent cardiopulmonary exercise testing, echocardiography and blood examination including indicators of nutrition at the same time in our hospital. The patients were followed up [median period 766days (interquartile range 500-1060)] to register cardiac deaths and rehospitalization due to worsening heart failure. There were 180 cardiac events during the follow-up periods. Patients with cardiac events had lower cholinesterase level than those without events (P<0.001). On the receiver operating characteristic analysis, the best cut-off value for cholinesterase was 240 U/l (area under the curve 0.720). In the Kaplan-Meier analysis, patients with cholinesterase<240 U/l had significantly higher cardiac event rates than those with cholinesterase>240 U/l. Multivariable Cox proportional hazards model demonstrated that NYHA class III [hazard ratio (HR): 1.688, 95% confidence interval (CI) 1.062-2.684, P=0.027], eGFR (HR: 0.983, 95% CI 0.971-0.995, P=0.006), sodium concentration (HR: 0.947, 95% CI 0.897-0.999, P<0.046), log BNP (HR: 1.880, 95% CI 1.509-2.341, P<0.001), cholinesterase (HR: 0.996, 95% CI 0.993-0.998, P=0.002) and exertional periodic breathing (HR: 1.619, 95% CI 1.098-2.388, P=0.015) were independent factors to predict adverse clinical outcomes. Serum cholinesterase level was an important prognostic factor in CHF. Springer Japan, 2014 Clinical outcome nationallicence Cholinesterase nationallicence Malnutrition nationallicence Liver function nationallicence Sato Takamasa Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut Yamauchi Hiroyuki Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut Suzuki Satoshi Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut Yoshihisa Akiomi Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut Yamaki Takayoshi Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut Sugimoto Koichi Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut Kunii Hiroyuki Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut Nakazato Kazuhiko Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut Suzuki Hitoshi Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut Saitoh Shu-ichi Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut Takeishi Yasuchika Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut Heart and Vessels Springer Japan 30/2(2015-03-01), 204-210 0910-8327 30:2<204 2015 30 380 https://doi.org/10.1007/s00380-014-0469-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0469-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sato Takamasa Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut NATIONALLICENCE 700 1- Yamauchi Hiroyuki Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut NATIONALLICENCE 700 1- Suzuki Satoshi Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut NATIONALLICENCE 700 1- Yoshihisa Akiomi Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut NATIONALLICENCE 700 1- Yamaki Takayoshi Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut NATIONALLICENCE 700 1- Sugimoto Koichi Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut NATIONALLICENCE 700 1- Kunii Hiroyuki Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut NATIONALLICENCE 700 1- Nakazato Kazuhiko Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut NATIONALLICENCE 700 1- Suzuki Hitoshi Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut NATIONALLICENCE 700 1- Saitoh Shu-ichi Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut NATIONALLICENCE 700 1- Takeishi Yasuchika Department of Cardiology and Hematology, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/2(2015-03-01), 204-210 0910-8327 30:2<204 2015 30 380