caa a22 4500 606221611 CHVBK 20210128101129.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00380-014-0470-2 doi (NATIONALLICENCE)springer-10.1007/s00380-014-0470-2 Implications of pentraxin 3 levels in patients with acute aortic dissection [Elektronische Daten] [Kenshiro Arao, Takayuki Fujiwara, Yousuke Taniguchi, Hiroyuki Jinnouchi, Harue Sasai, Mitsunari Matsumoto, Hiroshi Funayama, Junya Ako, Shin-ichi Momomura] Acute aortic dissection (AAD) causes transient inflammation with occasional pleural fluid (PF) accumulation. Although pentraxin 3 (PTX3) is a vascular inflammation-related biomarker, little is known about PTX3 levels in patients with AAD. We explored the serial changes in plasma PTX3 levels and the association of peak levels with the amount of PF accumulation. Consecutive patients (n=41) with Stanford type B AAD were enrolled, and blood samples for the measurements of serum albumin, plasma PTX3 and high-sensitivity C-reactive protein (CRP) were collected daily until 7days after symptom onset. PF accumulation on computed tomography imaging on the third hospital day was divided into 3 grades (I: none or slight, II: mild in the uni- or bilateral pleural cavity, III: moderate or more). PTX3 and CRP levels were analyzed after logarithmic transformation because of their skewed distributions. Peak PTX3 and CRP levels were observed at 4.3±2.1 and 4.7±2.0days after symptom onset, and their values were 12.2 [interquartile range (IQR), 8.2-20.9] ng/mL and 12.0 (IQR, 8.6-15.2) mg/dL, respectively. On univariate analysis, the peak level of PTX3 had a negative correlation with the minimum level of serum albumin, and a positive correlation with PF grade and duration of intensive care unit stay. On multivariate analysis, the peak level of PTX3 was correlated with PF grade (P=0.037). In conclusion, the peak level of PTX3 in patients with AAD was associated with the amount of transient PF accumulation, which may be associated with inflammatory vascular permeability. Springer Japan, 2014 Acute aortic dissection nationallicence Inflammation nationallicence Pentraxin 3 nationallicence Pleural fluid accumulation nationallicence Arao Kenshiro Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Japan aut Fujiwara Takayuki Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Japan aut Taniguchi Yousuke Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Japan aut Jinnouchi Hiroyuki Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Japan aut Sasai Harue Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Japan aut Matsumoto Mitsunari Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Japan aut Funayama Hiroshi Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Japan aut Ako Junya Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Japan aut Momomura Shin-ichi Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Japan aut Heart and Vessels Springer Japan 30/2(2015-03-01), 211-217 0910-8327 30:2<211 2015 30 380 https://doi.org/10.1007/s00380-014-0470-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00380-014-0470-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Arao Kenshiro Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Japan aut NATIONALLICENCE 700 1- Fujiwara Takayuki Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Japan aut NATIONALLICENCE 700 1- Taniguchi Yousuke Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Japan aut NATIONALLICENCE 700 1- Jinnouchi Hiroyuki Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Japan aut NATIONALLICENCE 700 1- Sasai Harue Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Japan aut NATIONALLICENCE 700 1- Matsumoto Mitsunari Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Japan aut NATIONALLICENCE 700 1- Funayama Hiroshi Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Japan aut NATIONALLICENCE 700 1- Ako Junya Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Japan aut NATIONALLICENCE 700 1- Momomura Shin-ichi Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, 330-8503, Saitama, Japan aut NATIONALLICENCE 773 0- Heart and Vessels Springer Japan 30/2(2015-03-01), 211-217 0910-8327 30:2<211 2015 30 380