caa a22 4500 606221832 CHVBK 20210128101130.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00038-015-0698-3 doi (NATIONALLICENCE)springer-10.1007/s00038-015-0698-3 Cardiovascular disease among people with drug use disorders [Elektronische Daten] [Birgitte Thylstrup, Thomas Clausen, Morten Hesse] Objectives: To present the prevalence and incidence of cardiovascular disease (CVD) in a national cohort of patients seeking treatment for drug use disorders (DUD). Methods: This is a longitudinal record linkage study of consecutive DUD treatment admissions between 2000 and 2006 from Denmark. Results: Of 17,642 patients seeking treatment for DUD, 828 individuals (4.53%) had a history of CVD at treatment entry. Among the remaining patients, 16,820 were traced and 1535 new incident cases of CVD were observed during a mean follow-up time of 7.5years. The incidence of CVD was associated with intravenous drug use [subhazard ratio (SHR)=1.41, p<0.001], not responding to injection question (SHR=1.23, p=0.005), older age (SHR=1.04 per year, p=0.000), use of prescription methadone (SHR=1.32, p<0.001), use of benzodiazepines (SHR=1.21, p=0.005), and being referred to methadone treatment (SHR=1.15, p=0.022). The use of amphetamines was negatively associated with the risk of CVD within this cohort (SHR=0.75, p=0.001). Conclusions: Patients injecting drugs using prescribed methadone were at elevated risk for cardiovascular disease and should be monitored for CVD. Opioid medications should be evaluated in terms of their cardiovascular sequelae. Swiss School of Public Health, 2015 Cardiovascular disease nationallicence Methadone nationallicence Injection drug use nationallicence Substance abuse treatment nationallicence Opioids nationallicence Amphetamine nationallicence Thylstrup Birgitte Aarhus University, Copenhagen, Denmark aut Clausen Thomas Institute of Clinical Medicine, SERAF—Norwegian Centre for Addiction Research, Kirkeveien 166, building 45, SERAF, Postbox 1039 Blindern, 0315, Oslo, Norway aut Hesse Morten Aarhus University, Copenhagen, Denmark aut International Journal of Public Health Springer Basel 60/6(2015-09-01), 659-668 1661-8556 60:6<659 2015 60 38 https://doi.org/10.1007/s00038-015-0698-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00038-015-0698-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Thylstrup Birgitte Aarhus University, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Clausen Thomas Institute of Clinical Medicine, SERAF—Norwegian Centre for Addiction Research, Kirkeveien 166, building 45, SERAF, Postbox 1039 Blindern, 0315, Oslo, Norway aut NATIONALLICENCE 700 1- Hesse Morten Aarhus University, Copenhagen, Denmark aut NATIONALLICENCE 773 0- International Journal of Public Health Springer Basel 60/6(2015-09-01), 659-668 1661-8556 60:6<659 2015 60 38