caa a22 4500 606222030 CHVBK 20210128101131.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00038-015-0714-7 doi (NATIONALLICENCE)springer-10.1007/s00038-015-0714-7 Considering treatment of male genital schistosomiasis as a tool for future HIV prevention: a systematic review [Elektronische Daten] [Chalotte Stecher, Per Kallestrup, Eyrun Kjetland, Birgitte Vennervald, Eskild Petersen] Objectives: Male genital schistosomiasis (MGS) is a neglected manifestation of Schistosoma haematobium infection with ignored implications on reproductive health and a differential diagnosis to sexually transmitted infections in endemic regions. MGS may have associations with HIV transmission and acquisition, and treatment could be a neglected chance of HIV prevention. This review summarizes current knowledge on epidemiology, clinical manifestations, diagnosis and treatment of MGS as a hypothesized risk factor for HIV transmission. Future research areas of global interest are suggested. Methods: PubMed published literature was reviewed based on the MOOSE guidelines. All publications on MGS were included regardless of publication year and study design. Furthermore, all publications were searched for information on possible HIV association. Results: The 40 identified publications related to MGS were dominated by case reports and observational studies. No randomized clinical trials have been conducted to date, and very scant information related to possible associations with HIV transmission was presented. Conclusions: Clinical, randomized studies and epidemiological studies covering the possible association between MGS and HIV are urgently needed. Furthermore, field diagnostic tools should be developed and future mass treatment programs should include adults to reduce morbidity and prevent HIV acquisition. Systematic review registration number: CRD42015016252. Swiss School of Public Health, 2015 Male nationallicence Genital nationallicence Schistosomiasis nationallicence HIV nationallicence MGS nationallicence Stecher Chalotte Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark aut Kallestrup Per Center for Global Health (GloHAU), Aarhus University, Aarhus, Denmark aut Kjetland Eyrun Norwegian Centre for Imported and Tropical Diseases, Oslo University Hospital, Oslo, Norway aut Vennervald Birgitte Department of Parasitology and Aquatic Diseases, University of Copenhagen, Copenhagen, Denmark aut Petersen Eskild Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark aut International Journal of Public Health Springer Basel 60/7(2015-11-01), 839-848 1661-8556 60:7<839 2015 60 38 https://doi.org/10.1007/s00038-015-0714-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00038-015-0714-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stecher Chalotte Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark aut NATIONALLICENCE 700 1- Kallestrup Per Center for Global Health (GloHAU), Aarhus University, Aarhus, Denmark aut NATIONALLICENCE 700 1- Kjetland Eyrun Norwegian Centre for Imported and Tropical Diseases, Oslo University Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Vennervald Birgitte Department of Parasitology and Aquatic Diseases, University of Copenhagen, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Petersen Eskild Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark aut NATIONALLICENCE 773 0- International Journal of Public Health Springer Basel 60/7(2015-11-01), 839-848 1661-8556 60:7<839 2015 60 38