caa a22 4500 606222375 CHVBK 20210128101133.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00038-015-0676-9 doi (NATIONALLICENCE)springer-10.1007/s00038-015-0676-9 Evaluating HIV prevention strategies for populations in key affected groups: the example of Cabo Verde [Elektronische Daten] [João Monteiro, Sandro Galea, Timothy Flanigan, Maria Monteiro, Samuel Friedman, Brandon Marshall] Objectives: We used an individual-based model to evaluate the effects of hypothetical prevention interventions on HIV incidence trajectories in a concentrated, mixed epidemic setting from 2011 to 2021, and using Cabo Verde as an example. Methods: Simulations were conducted to evaluate the extent to which early HIV treatment and optimization of care, HIV testing, condom distribution, and substance abuse treatment could eliminate new infections (i.e., reduce incidence to less than 10 cases per 10,000 person-years) among non-drug users, female sex workers (FSW), and people who use drugs (PWUD). Results: Scaling up all four interventions resulted in the largest decreases in HIV, with estimates ranging from 1.4 (95% CI 1.36-1.44) per 10,000 person-years among non-drug users to 8.2 (95% CI 7.8-8.6) per 10,000 person-years among PWUD in 2021. Intervention scenarios prioritizing FWS and PWUD also resulted in HIV incidence estimates at or below 10 per 10,000 person-years by 2021 for all population sub-groups. Conclusions: Our results suggest that scaling up multiple interventions among entire population is necessary to achieve elimination. However, prioritizing key populations with this combination prevention strategy may also result in a substantial decrease in total incidence. Swiss School of Public Health, 2015 Individual-based model nationallicence Condom use nationallicence Female sex workers nationallicence Monte Carlo simulation nationallicence People who use drugs nationallicence Substance use nationallicence Monteiro João Department of Epidemiology, Brown University School of Public Health, 121 South Main Street, Box G-S-121-2, 02912, Providence, RI, USA aut Galea Sandro Department of Epidemiology, Columbia University Mailman School of Public Health, 722 West 168th Street, Room 1508, 10032, New York, NY, USA aut Flanigan Timothy Division of Infectious Diseases, The Miriam Hospital, 1125 North Main Street, 02906, Providence, RI, USA aut Monteiro Maria Ministério da Saúde, Palácio do Governo, Praia, C.P. 47, Ilha De Santiago, Cabo Verde aut Friedman Samuel Institute for Infectious Disease Research, National Development and Research Institutes Inc., 71 West 23rd Street, 8th Floor, 10010, New York, NY, USA aut Marshall Brandon Department of Epidemiology, Brown University School of Public Health, 121 South Main Street, Box G-S-121-2, 02912, Providence, RI, USA aut International Journal of Public Health Springer Basel 60/4(2015-05-01), 457-466 1661-8556 60:4<457 2015 60 38 https://doi.org/10.1007/s00038-015-0676-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00038-015-0676-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Monteiro João Department of Epidemiology, Brown University School of Public Health, 121 South Main Street, Box G-S-121-2, 02912, Providence, RI, USA aut NATIONALLICENCE 700 1- Galea Sandro Department of Epidemiology, Columbia University Mailman School of Public Health, 722 West 168th Street, Room 1508, 10032, New York, NY, USA aut NATIONALLICENCE 700 1- Flanigan Timothy Division of Infectious Diseases, The Miriam Hospital, 1125 North Main Street, 02906, Providence, RI, USA aut NATIONALLICENCE 700 1- Monteiro Maria Ministério da Saúde, Palácio do Governo, Praia, C.P. 47, Ilha De Santiago, Cabo Verde aut NATIONALLICENCE 700 1- Friedman Samuel Institute for Infectious Disease Research, National Development and Research Institutes Inc., 71 West 23rd Street, 8th Floor, 10010, New York, NY, USA aut NATIONALLICENCE 700 1- Marshall Brandon Department of Epidemiology, Brown University School of Public Health, 121 South Main Street, Box G-S-121-2, 02912, Providence, RI, USA aut NATIONALLICENCE 773 0- International Journal of Public Health Springer Basel 60/4(2015-05-01), 457-466 1661-8556 60:4<457 2015 60 38