caa a22 4500 60622937X CHVBK 20210128101208.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10796-012-9406-5 doi (NATIONALLICENCE)springer-10.1007/s10796-012-9406-5 An integrated systems approach to plateau ecosystem management—a scientific application in Qinghai and Tibet plateau [Elektronische Daten] [Fang Liu, Zhuming Bi, Eric Xu, Qin Ga, Quanyu Yang, Yingzhong Yang, Lan Ma, Tana Wuren, Rili Ge] There is a global trend of the shortage of nature resources, such as water and wildlife, which have suffered dramatic losses due to over-use, pollution, habitat loss, and, increasingly, changes caused by global warming. To make the planet more sustainable, abundant data has to be collected and analyzed from ecosystems for scientific decision-making, restoring and preserving natural resources. In this paper, an integrated systems approach has been proposed for the data acquisition and analysis in information management of an ecosystem; it is a direct extension of an agriculture ecosystem enterprise information system (AEEIS) developed by Xu et al. (Genomics Proteomics Bioinformatics 3:5-17, 2008). The challenges in system development have been discussed, and the significance of the developed system has been illustrated through a thorough discussion and a case study on the genetic coding and expression of antelopes. In the case study, an IoT-based enterprise information system (EIS) has been applied to investigate the effects of the signal transducer and activator of transcription 3 (STAT3) on the adaptation mechanism to high altitude hypoxia. Two remarkable conclusions are (i) the levels of the STAT3 mRNA and protein vary from one tissue to another, and the highest level is in the lung tissue, and (ii) Tibetan antelope's expression of STAT3 mRNA and protein are higher than that from plain sheep. Based on the fact that a Tibetan antelope has a higher adaptability to hypoxia; it has illustrated that the hypoxic STAT3-specific expression is one of the molecular bases of high altitude hypoxia adaptation in Tibetan antelope. Springer Science+Business Media New York, 2012 Medical Informatics nationallicence Enterprise Systems nationallicence Industrial Information Integration Engineering (IIIE) nationallicence Internet of Things (IoT) nationallicence Ecosystem nationallicence Signal Transducer and Activator of Transcription 3 nationallicence Genetic Cloning nationallicence Genetic Expression nationallicence Hypoxia Adaptation nationallicence AEEIS : Agriculture ecosystem enterprise information system nationallicence bp : Base pair nationallicence cDNA : Complementary deoxyribonucleic acid nationallicence CDS : Coding sequence nationallicence DBD : Deoxyribonucleic acid binding domain nationallicence DNase : Deoxyribonuclease nationallicence DNA : Deoxyribonucleic acid nationallicence mRNA : Messenger ribonucleic acid nationallicence MnSOD : Manganese superoxide dismutase nationallicence NST : Non shivering thermogenesis nationallicence ORF : Open reading frames nationallicence RACE : Rapid amplification of cDNA ends nationallicence RNA : Ribonucleic acid nationallicence RT-PCR : Real-time polymerase chain reaction nationallicence SH2 : Src homology 2 domain nationallicence SoS : System of systems nationallicence STAT3 : Signal transducer and activator of transcription 3 nationallicence TAD : Transcription activation domain nationallicence UTR : Untranslated region nationallicence UCP1 : Uncoupling proteins 1 nationallicence VEGF : Vascular endothelial growth factor nationallicence Liu Fang Research Center for High Altitude Medical Sciences, Medical College, Qinghai University, 810001, Xining, China aut Bi Zhuming Department of Engineering, Indiana University Purdue University Fort Wayne, 46805, Fort Wayne, IN, USA aut Xu Eric College of Physicians and Surgeons, Columbia University, 10032, New York, NY, USA aut Ga Qin Research Center for High Altitude Medical Sciences, Medical College, Qinghai University, 810001, Xining, China aut Yang Quanyu Research Center for High Altitude Medical Sciences, Medical College, Qinghai University, 810001, Xining, China aut Yang Yingzhong Research Center for High Altitude Medical Sciences, Medical College, Qinghai University, 810001, Xining, China aut Ma Lan Research Center for High Altitude Medical Sciences, Medical College, Qinghai University, 810001, Xining, China aut Wuren Tana Research Center for High Altitude Medical Sciences, Medical College, Qinghai University, 810001, Xining, China aut Ge Rili Research Center for High Altitude Medical Sciences, Medical College, Qinghai University, 810001, Xining, China aut Information Systems Frontiers Springer US; http://www.springer-ny.com 17/2(2015-04-01), 337-350 1387-3326 17:2<337 2015 17 10796 https://doi.org/10.1007/s10796-012-9406-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10796-012-9406-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Fang Research Center for High Altitude Medical Sciences, Medical College, Qinghai University, 810001, Xining, China aut NATIONALLICENCE 700 1- Bi Zhuming Department of Engineering, Indiana University Purdue University Fort Wayne, 46805, Fort Wayne, IN, USA aut NATIONALLICENCE 700 1- Xu Eric College of Physicians and Surgeons, Columbia University, 10032, New York, NY, USA aut NATIONALLICENCE 700 1- Ga Qin Research Center for High Altitude Medical Sciences, Medical College, Qinghai University, 810001, Xining, China aut NATIONALLICENCE 700 1- Yang Quanyu Research Center for High Altitude Medical Sciences, Medical College, Qinghai University, 810001, Xining, China aut NATIONALLICENCE 700 1- Yang Yingzhong Research Center for High Altitude Medical Sciences, Medical College, Qinghai University, 810001, Xining, China aut NATIONALLICENCE 700 1- Ma Lan Research Center for High Altitude Medical Sciences, Medical College, Qinghai University, 810001, Xining, China aut NATIONALLICENCE 700 1- Wuren Tana Research Center for High Altitude Medical Sciences, Medical College, Qinghai University, 810001, Xining, China aut NATIONALLICENCE 700 1- Ge Rili Research Center for High Altitude Medical Sciences, Medical College, Qinghai University, 810001, Xining, China aut NATIONALLICENCE 773 0- Information Systems Frontiers Springer US; http://www.springer-ny.com 17/2(2015-04-01), 337-350 1387-3326 17:2<337 2015 17 10796