caa a22 4500 606229922 CHVBK 20210128101211.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10695-015-0035-z doi (NATIONALLICENCE)springer-10.1007/s10695-015-0035-z Nephroprotective and antioxidant significance of selenium and α-tocopherol on lead acetate-induced toxicity of Nile Tilapia ( Oreochromis niloticus ) [Elektronische Daten] [Emad Hashish, Shimaa Elgaml, Abdelhakeem El-Murr, Ryad Khalil] The kidney plays an important physiological function, maintaining the osmoregulation and electrolyte balance of Nile tilapia (Oreochromis niloticus). Selenium and α-tocopherol (α-toc) are potent antioxidants, which improve the aquaculture health. In this study, we tested the potential ability of selenium and α-toc to alleviate the oxidative stress in the kidney induced by lead toxicity. Two hundred and twenty-five O. niloticus were divided into five groups. The control group received a basal diet. Lead nephrotoxicity was induced by daily application of 73.40mg lead acetate/liter water for up to 10weeks. Selenium and α-tocopherol were given 1week before lead intoxication. Selenium was administered as sodium selenite, 4mg/kg dry diet. Alpha-tocopherol acetate was administered as α-toc, 200mg/kg dry diet. The last group received a mixture of selenium and α-toc in diet. Fish treated with selenium and/or α-toc (groups III-V) showed an amelioration of the adverse effects of lead toxicity and significant improvement in serum electrolytes (calcium, inorganic phosphate, and magnesium) and creatinine level compared with the positive control group (P≤0.05). Treated groups showed significant decrease in superoxide dismutase (SOD) and reduced glutathione (GSH) activity with significant increase in malondialdehyde (MDA; P≤0.05). It could be concluded that selenium and α-toc have a potential antioxidant effect and have the ability to improve the kidney function after lead intoxication of O. niloticus. Springer Science+Business Media Dordrecht, 2015 Oreochromis niloticus nationallicence Selenium nationallicence α-Tocopherol nationallicence Lead acetate nationallicence Serum electrolytes nationallicence Antioxidants nationallicence Hashish Emad Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt aut Elgaml Shimaa Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt aut El-Murr Abdelhakeem Department of Fish Diseases and Management, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt aut Khalil Ryad Department of Poultry and Fish Diseases, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt aut Fish Physiology and Biochemistry Springer Netherlands 41/3(2015-06-01), 651-660 0920-1742 41:3<651 2015 41 10695 https://doi.org/10.1007/s10695-015-0035-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10695-015-0035-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hashish Emad Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt aut NATIONALLICENCE 700 1- Elgaml Shimaa Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt aut NATIONALLICENCE 700 1- El-Murr Abdelhakeem Department of Fish Diseases and Management, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt aut NATIONALLICENCE 700 1- Khalil Ryad Department of Poultry and Fish Diseases, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt aut NATIONALLICENCE 773 0- Fish Physiology and Biochemistry Springer Netherlands 41/3(2015-06-01), 651-660 0920-1742 41:3<651 2015 41 10695