caa a22 4500 606229973 CHVBK 20210128101211.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s10695-015-0047-8 doi (NATIONALLICENCE)springer-10.1007/s10695-015-0047-8 Comparative pharmacokinetics of oxytetracycline in blunt-snout bream ( Megalobrama amblycephala ) with single and multiple-dose oral administration [Elektronische Daten] [Ru-Qin Li, Yu-Wei Ren, Jing Li, Can Huang, Jun-hui Shao, Xiao-Xuan Chen, Zhi-Xin Wu] Research into the pharmacokinetics and residue elimination of oxytetracycline (OTC) is important both to determine the optimal dosage regimens and to establish a safe withdrawal time in fish. A depletion study is presented here for OTC in Megalobrama amblycephala with a single-dose (100mg/kg) and multiple-dose (100mg/kg for five consecutive days) oral administration. The study was conducted at 25°C. As a result, a one-compartment model was developed. For the single dose, the absorption half-life was 5.79, 9.40, 6.96, and 8.06h in the plasma, liver, kidney, and muscle, respectively. However, the absorption half-life was 3.62, 7.33, 4.59, and 6.02h with multiple-dose oral administration. The elimination half-time in the plasma, liver, kidney, and muscle was 58.63, 126.43, 65.1, and 58.85h when M. amblycephala was treated with a single dose. However, the elimination half-time changed to 91.75, 214.87, 126.22, and 135.84h with multiple-dose oral administration. Springer Science+Business Media Dordrecht, 2015 Pharmacokinetics nationallicence Oxytetracycline nationallicence Megalobrama amblycephala nationallicence Oral administration nationallicence Li Ru-Qin Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Freshwater Aquaculture Collaborative Innovation Center, 430070, Wuhan, Hubei Province, China aut Ren Yu-Wei Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Freshwater Aquaculture Collaborative Innovation Center, 430070, Wuhan, Hubei Province, China aut Li Jing Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Freshwater Aquaculture Collaborative Innovation Center, 430070, Wuhan, Hubei Province, China aut Huang Can Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Freshwater Aquaculture Collaborative Innovation Center, 430070, Wuhan, Hubei Province, China aut Shao Jun-hui Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Freshwater Aquaculture Collaborative Innovation Center, 430070, Wuhan, Hubei Province, China aut Chen Xiao-Xuan Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Freshwater Aquaculture Collaborative Innovation Center, 430070, Wuhan, Hubei Province, China aut Wu Zhi-Xin Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Freshwater Aquaculture Collaborative Innovation Center, 430070, Wuhan, Hubei Province, China aut Fish Physiology and Biochemistry Springer Netherlands 41/3(2015-06-01), 803-809 0920-1742 41:3<803 2015 41 10695 https://doi.org/10.1007/s10695-015-0047-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10695-015-0047-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Ru-Qin Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Freshwater Aquaculture Collaborative Innovation Center, 430070, Wuhan, Hubei Province, China aut NATIONALLICENCE 700 1- Ren Yu-Wei Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Freshwater Aquaculture Collaborative Innovation Center, 430070, Wuhan, Hubei Province, China aut NATIONALLICENCE 700 1- Li Jing Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Freshwater Aquaculture Collaborative Innovation Center, 430070, Wuhan, Hubei Province, China aut NATIONALLICENCE 700 1- Huang Can Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Freshwater Aquaculture Collaborative Innovation Center, 430070, Wuhan, Hubei Province, China aut NATIONALLICENCE 700 1- Shao Jun-hui Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Freshwater Aquaculture Collaborative Innovation Center, 430070, Wuhan, Hubei Province, China aut NATIONALLICENCE 700 1- Chen Xiao-Xuan Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Freshwater Aquaculture Collaborative Innovation Center, 430070, Wuhan, Hubei Province, China aut NATIONALLICENCE 700 1- Wu Zhi-Xin Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural University, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Freshwater Aquaculture Collaborative Innovation Center, 430070, Wuhan, Hubei Province, China aut NATIONALLICENCE 773 0- Fish Physiology and Biochemistry Springer Netherlands 41/3(2015-06-01), 803-809 0920-1742 41:3<803 2015 41 10695