caa a22 4500 60623098X CHVBK 20210128101217.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10508-015-0545-x doi (NATIONALLICENCE)springer-10.1007/s10508-015-0545-x Sexual Response in Women with Type 1 Diabetes Mellitus: A Controlled Laboratory Study Measuring Vaginal Blood Flow and Subjective Sexual Arousal [Elektronische Daten] [Stephanie Both, Moniek ter Kuile, Paul Enzlin, Olaf Dekkers, Marieke van Dijk, Philomeen Weijenborg] Previous studies have indicated that women with diabetes mellitus are at higher risk to develop sexual dysfunctions. In the current study, we hypothesized that lower genital arousal response—as a consequence of diabetes-related damage to nerves and blood vessels—might play a part in these higher prevalence rates. Vaginal blood flow, subjective sexual response, and clitoral sensitivity were compared between women with diabetes and healthy controls, and associations with diabetes complications were investigated. In pre- and postmenopausal women with type 1 diabetes (n=42) and healthy controls (n=46), vaginal blood flow was measured as vaginal pulse amplitude (VPA). VPA was assessed at rest, during erotic film viewing, and during vibrotactile clitoral stimulation. Subjective sexual arousal was measured using a questionnaire. Clitoral sensitivity was assessed by a vibration perception test. Data on diabetes complications were obtained from medical records, and neuropathy was assessed by quantitative sensory testing. VPA, subjective sexual arousal, and clitoral sensitivity were not significantly different between women with diabetes and controls. Nevertheless, women with diabetes who had retinopathy showed significantly lower VPA than women without retinopathy, and women with diabetes who had neuropathy showed significantly higher sensation thresholds for vibrotactile clitoral stimulation. The results do not support the hypothesis of a disrupted genital arousal response in women with diabetes. However, the observed associations between retinopathy and vaginal blood flow, and between neuropathy and clitoral sensitivity, suggest that diabetes-related complications might adversely affect the physiological basis of female sexual response. Springer Science+Business Media New York, 2015 Diabetes mellitus nationallicence Sexual behavior nationallicence Sexual dysfunction nationallicence Diabetes complications nationallicence Genitalia, female nationallicence Vaginal photoplethysmography nationallicence Both Stephanie Department of Psychosomatic Gynecology and Sexology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands aut ter Kuile Moniek Department of Psychosomatic Gynecology and Sexology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands aut Enzlin Paul Department of Obstetrics and Gynecology, Institute for Family and Sexuality Studies, University of Leuven, Louvain, Belgium aut Dekkers Olaf Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, The Netherlands aut van Dijk Marieke Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, The Netherlands aut Weijenborg Philomeen Department of Psychosomatic Gynecology and Sexology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands aut Archives of Sexual Behavior Springer US; http://www.springer-ny.com 44/6(2015-08-01), 1573-1587 0004-0002 44:6<1573 2015 44 10508 https://doi.org/10.1007/s10508-015-0545-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10508-015-0545-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Both Stephanie Department of Psychosomatic Gynecology and Sexology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands aut NATIONALLICENCE 700 1- ter Kuile Moniek Department of Psychosomatic Gynecology and Sexology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Enzlin Paul Department of Obstetrics and Gynecology, Institute for Family and Sexuality Studies, University of Leuven, Louvain, Belgium aut NATIONALLICENCE 700 1- Dekkers Olaf Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, The Netherlands aut NATIONALLICENCE 700 1- van Dijk Marieke Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, The Netherlands aut NATIONALLICENCE 700 1- Weijenborg Philomeen Department of Psychosomatic Gynecology and Sexology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands aut NATIONALLICENCE 773 0- Archives of Sexual Behavior Springer US; http://www.springer-ny.com 44/6(2015-08-01), 1573-1587 0004-0002 44:6<1573 2015 44 10508