caa a22 4500 606231129 CHVBK 20210128101218.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10508-015-0530-4 doi (NATIONALLICENCE)springer-10.1007/s10508-015-0530-4 A Pilot Study on Tamoxifen Sexual Side Effects and Hand Preference in Male Breast Cancer [Elektronische Daten] [Ion Motofei, David Rowland, Florian Popa, Eugen Bratucu, Dan Straja, Mirela Manea, Simona Georgescu, Stana Paunica, Mircea Bratucu, Cristian Balalau, Vlad Constantin] Recent clinical and imaging studies suggest that sex hormones modulate sexuality according to a psychophysiologic process of lateralization of the brain, with androgens playing a greater role in sexual functioning of left hemibrain/right handedness and estrogens possibly for right hemibrain/left handedness. Based on this perspective, the current study attempted to specify the relationship between hand preference, estrogens, and sexual function in subjects with male breast cancer, taking into account the sexual side effects of tamoxifen as the agent for inhibiting estrogen action. Twenty-eight Romanian men—17 right-handed and 11 left-handed—undergoing treatment with tamoxifen for male breast cancer participated in this study. These men were assessed both prior to and during tamoxifen treatment using the International Index of Erectile Function, a standardized instrument used for the evaluation of various aspects of sexual functioning, including erectile function (EF), orgasmic function (OF), sexual desire (SD), and overall functioning (OF). A main effect for handedness was found on EF, OF, SD, and OS scales, with right-handed men showing higher functioning than left-handed men. Regarding interaction effects, the left-handed group of men showed greater decreased sexual functioning during tamoxifen (on three subscales: OF, SD, OS) compared to right-handed men. Further research should be conducted in order to support and refine this potential lateralized process of sexual neuromodulation within the brain. Springer Science+Business Media New York, 2015 Tamoxifen nationallicence Estrogens nationallicence Sexual side effects nationallicence Handedness nationallicence Male breast cancer nationallicence Motofei Ion Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut Rowland David Department of Psychology, Valparaiso University Graduate School, Valparaiso, IN, USA aut Popa Florian Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut Bratucu Eugen Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut Straja Dan Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut Manea Mirela Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut Georgescu Simona Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut Paunica Stana Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut Bratucu Mircea Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut Balalau Cristian Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut Constantin Vlad Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut Archives of Sexual Behavior Springer US; http://www.springer-ny.com 44/6(2015-08-01), 1589-1594 0004-0002 44:6<1589 2015 44 10508 https://doi.org/10.1007/s10508-015-0530-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10508-015-0530-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Motofei Ion Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut NATIONALLICENCE 700 1- Rowland David Department of Psychology, Valparaiso University Graduate School, Valparaiso, IN, USA aut NATIONALLICENCE 700 1- Popa Florian Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut NATIONALLICENCE 700 1- Bratucu Eugen Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut NATIONALLICENCE 700 1- Straja Dan Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut NATIONALLICENCE 700 1- Manea Mirela Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut NATIONALLICENCE 700 1- Georgescu Simona Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut NATIONALLICENCE 700 1- Paunica Stana Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut NATIONALLICENCE 700 1- Bratucu Mircea Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut NATIONALLICENCE 700 1- Balalau Cristian Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut NATIONALLICENCE 700 1- Constantin Vlad Faculty of General Medicine, Carol Davila University of Medicine and Pharmacy, Cazangiilor Street, No. 10, Sect.3, 03306, Bucharest, Romania aut NATIONALLICENCE 773 0- Archives of Sexual Behavior Springer US; http://www.springer-ny.com 44/6(2015-08-01), 1589-1594 0004-0002 44:6<1589 2015 44 10508