caa a22 4500 606232133 CHVBK 20210128101224.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s10508-015-0629-7 doi (NATIONALLICENCE)springer-10.1007/s10508-015-0629-7 Diffusion Tensor Imaging of Pedophilia [Elektronische Daten] [James Cantor, Sophie Lafaille, Debra Soh, Massieh Moayedi, David Mikulis, Todd Girard] Pedophilia is a principal motivator of child molestation, incurring great emotional and financial burdens on victims and society. Even among pedophiles who never commit any offense, the condition requires lifelong suppression and control. Previous comparison using voxel-based morphometry (VBM) of MR images from a large sample of pedophiles and controls revealed group differences in white matter. The present study therefore sought to verify and characterize white matter involvement using diffusion tensor imaging (DTI), which better captures the microstructure of white matter than does VBM. Pedophilic sex offenders (n=24) were compared with healthy, age-matched controls with no criminal record and no indication of pedophilia (n=32). White matter microstructure was analyzed with Tract-Based Spatial Statistics, and the trajectories of implicated fiber bundles were identified by probabilistic tractography. Groups showed significant, highly focused differences in DTI parameters which related to participants' genital responses to sexual depictions of children, but not to measures of psychopathy or to childhood histories of physical abuse, sexual abuse, or neglect. Some previously reported gray matter differences were suggested under highly liberal statistical conditions (p uncorrected<.005), but did not survive ordinary statistical correction (whole brain per voxel false discovery rate of 5%). These results confirm that pedophilia is characterized by neuroanatomical differences in white matter microstructure, over and above any neural characteristics attributable to psychopathy and childhood adversity, which show neuroanatomic footprints of their own. Although some gray matter structures were implicated previously, only few have emerged reliably. Springer Science+Business Media New York, 2015 DSM-5 nationallicence Fractional anisotropy nationallicence Hebephilia nationallicence Paraphilia nationallicence Pedophilia nationallicence Probabilistic tractography nationallicence Cantor James Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada aut Lafaille Sophie Complex Mental Illness Program, Centre for Addiction and Mental Health, Toronto, ON, Canada aut Soh Debra Department of Psychology, York University, Toronto, ON, Canada aut Moayedi Massieh Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK aut Mikulis David Toronto Western Research Institute, University Health Network, Toronto, ON, Canada aut Girard Todd Department of Psychology, Ryerson University, Toronto, ON, Canada aut Archives of Sexual Behavior Springer US; http://www.springer-ny.com 44/8(2015-11-01), 2161-2172 0004-0002 44:8<2161 2015 44 10508 https://doi.org/10.1007/s10508-015-0629-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10508-015-0629-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cantor James Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Lafaille Sophie Complex Mental Illness Program, Centre for Addiction and Mental Health, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Soh Debra Department of Psychology, York University, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Moayedi Massieh Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK aut NATIONALLICENCE 700 1- Mikulis David Toronto Western Research Institute, University Health Network, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Girard Todd Department of Psychology, Ryerson University, Toronto, ON, Canada aut NATIONALLICENCE 773 0- Archives of Sexual Behavior Springer US; http://www.springer-ny.com 44/8(2015-11-01), 2161-2172 0004-0002 44:8<2161 2015 44 10508