caa a22 4500 606232184 CHVBK 20210128101224.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s10508-015-0560-y doi (NATIONALLICENCE)springer-10.1007/s10508-015-0560-y Sex Differences in Neurophysiological Activation Patterns During Phonological Input Processing: An Influencing Factor for Normative Data [Elektronische Daten] [Annelies Aerts, Pieter van Mierlo, Robert Hartsuiker, Patrick Santens, Miet De Letter] In the context of neurophysiological normative data, it has been established that aging has a significant impact on neurophysiological correlates of auditory phonological input processes, such as phoneme discrimination (PD) and word recognition (WR). Besides age, sex is another demographic factor that influences several language processes. We aimed to disentangle whether sex has a similar effect on PD and WR. Event-related potentials (ERPs) were recorded in 20 men and 24 women. During PD, three phonemic contrasts (place and manner of articulation and voicing) were compared using the attentive P300 and pre-attentive Mismatch Negativity. To investigate WR, real words were contrasted with pseudowords in a pre-attentive oddball task. Women demonstrated a larger sensitivity to spectrotemporal differences, as evidenced by larger P300 responses to the place of articulation (PoA) contrast and larger P300 and MMN responses than men in PoA-based PD. Men did not display such sensitivity. Attention played an important role, considering that women needed more attentional resources to differentiate between PoA and the other phonemic contrasts. During WR, pseudowords evoked larger amplitudes already 100ms post-stimulus independent of sex. However, women had decreased P200 latencies, but longer N400 latencies in response to pseudowords, whereas men showed increased N400 latencies compared to women in response to real words. The current results demonstrate significant sex-related influences on phonological input processes. Therefore, existing neurophysiological normative data for age should be complemented for the factor sex. Springer Science+Business Media New York, 2015 Sex nationallicence Mismatch negativity (MMN) nationallicence P300 nationallicence Phonology nationallicence N400 pseudoword effect nationallicence Gender nationallicence Aerts Annelies Department of Internal Medicine, Ghent University Hospital, De Pintelaan 185 (1K12-IA), 9000, Ghent, Belgium aut van Mierlo Pieter Department of Electronics and Information Systems, Medical Image and Signal Processing Group, Ghent University, Ghent, Belgium aut Hartsuiker Robert Department of Experimental Psychology, Ghent University, Ghent, Belgium aut Santens Patrick Department of Internal Medicine, Ghent University Hospital, De Pintelaan 185 (1K12-IA), 9000, Ghent, Belgium aut De Letter Miet Department of Neurology, Ghent University Hospital, Ghent, Belgium aut Archives of Sexual Behavior Springer US; http://www.springer-ny.com 44/8(2015-11-01), 2207-2218 0004-0002 44:8<2207 2015 44 10508 https://doi.org/10.1007/s10508-015-0560-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10508-015-0560-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aerts Annelies Department of Internal Medicine, Ghent University Hospital, De Pintelaan 185 (1K12-IA), 9000, Ghent, Belgium aut NATIONALLICENCE 700 1- van Mierlo Pieter Department of Electronics and Information Systems, Medical Image and Signal Processing Group, Ghent University, Ghent, Belgium aut NATIONALLICENCE 700 1- Hartsuiker Robert Department of Experimental Psychology, Ghent University, Ghent, Belgium aut NATIONALLICENCE 700 1- Santens Patrick Department of Internal Medicine, Ghent University Hospital, De Pintelaan 185 (1K12-IA), 9000, Ghent, Belgium aut NATIONALLICENCE 700 1- De Letter Miet Department of Neurology, Ghent University Hospital, Ghent, Belgium aut NATIONALLICENCE 773 0- Archives of Sexual Behavior Springer US; http://www.springer-ny.com 44/8(2015-11-01), 2207-2218 0004-0002 44:8<2207 2015 44 10508