caa a22 4500 606233520 CHVBK 20210128101232.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s11010-015-2385-3 doi (NATIONALLICENCE)springer-10.1007/s11010-015-2385-3 Sundaram Susinder School of Chemical and Biotechnology, SASTRA University, Thanjavur, India aut Rac1 is a novel interactor of Drosophila guanine nucleotide exchange factor GEFmeso [Elektronische Daten] [Susinder Sundaram] Guanine nucleotide exchange factors (GEF) are proteins that regulate the activity of GTPases by catalysing the exchange of GDP for GTP. In this work, we studied the interaction of various Rho family GTPases CDC42, Rac1 and RhoA with GEFmeso, a GEF expressed in Drosophila melanogaster (fruit fly). The interaction of GEFmeso with Rho family GTPases was studied by means of guanine nucleotide exchange assays. Our results suggest that GEFmeso interacts with Rac1 in addition to its interaction with CDC42 and Ral, which was reported earlier. We propose that the guanine nucleotide exchange factor GEFmeso is involved in a developmental process that requires the synergistic action of CDC42 and Rac1 during Drosophila development. Springer Science+Business Media New York, 2015 GEF nationallicence Rac1 nationallicence RhoA nationallicence CDC42 nationallicence Guanine nucleotide exchange assay nationallicence Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 404/1-2(2015-06-01), 259-262 0300-8177 404:1-2<259 2015 404 11010 https://doi.org/10.1007/s11010-015-2385-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 brief-communication jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-015-2385-3 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Sundaram Susinder School of Chemical and Biotechnology, SASTRA University, Thanjavur, India aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 404/1-2(2015-06-01), 259-262 0300-8177 404:1-2<259 2015 404 11010