caa a22 4500 606233644 CHVBK 20210128101233.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s11010-015-2363-9 doi (NATIONALLICENCE)springer-10.1007/s11010-015-2363-9 BTG3 upregulation induces cell apoptosis and suppresses invasion in esophageal adenocarcinoma [Elektronische Daten] [Yuwen Du, Pingping Liu, Wenqiao Zang, Yuanyuan Wang, Xiaonan Chen, Min Li, Guoqiang Zhao] B cell translocation gene 3 (BTG3) is a tumor suppressor by inhibiting cell proliferation, migration, and regulating cell cycle progression in several tumors. However, its role in esophageal adenocarcinoma (EAC) remains unknown. Here, we detected the expression of BTG3 in EAC tissues and subsequent progression. BTG3 expression was significant decreased in EAC tissues and cell lines detected by real-time RT-PCR and Western blot. Relationships of BTG3 with EAC clinicopathology were analyzed statistically. The decrease expression of BTG3 is associated with lymph node metastases. In vitro assay demonstrated that overexpression of BTG3 significantly suppressed colony formation and proliferation of EAC cells. The suppressed migration and invasion abilities found in BTG3-overexpressing EAC cells. Our findings suggested that BTG3 is suppressor in the progression of EAC. Springer Science+Business Media New York, 2015 Esophageal adenocarcinoma nationallicence BTG3 nationallicence Proliferation nationallicence Migration nationallicence Du Yuwen College of Basic Medical Sciences, Zhengzhou University, No. 100 Kexue Road, 450001, Zhengzhou, China aut Liu Pingping College of Basic Medical Sciences, Zhengzhou University, No. 100 Kexue Road, 450001, Zhengzhou, China aut Zang Wenqiao College of Basic Medical Sciences, Zhengzhou University, No. 100 Kexue Road, 450001, Zhengzhou, China aut Wang Yuanyuan College of Basic Medical Sciences, Zhengzhou University, No. 100 Kexue Road, 450001, Zhengzhou, China aut Chen Xiaonan College of Basic Medical Sciences, Zhengzhou University, No. 100 Kexue Road, 450001, Zhengzhou, China aut Li Min College of Basic Medical Sciences, Zhengzhou University, No. 100 Kexue Road, 450001, Zhengzhou, China aut Zhao Guoqiang College of Basic Medical Sciences, Zhengzhou University, No. 100 Kexue Road, 450001, Zhengzhou, China aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 404/1-2(2015-06-01), 31-38 0300-8177 404:1-2<31 2015 404 11010 https://doi.org/10.1007/s11010-015-2363-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-015-2363-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Du Yuwen College of Basic Medical Sciences, Zhengzhou University, No. 100 Kexue Road, 450001, Zhengzhou, China aut NATIONALLICENCE 700 1- Liu Pingping College of Basic Medical Sciences, Zhengzhou University, No. 100 Kexue Road, 450001, Zhengzhou, China aut NATIONALLICENCE 700 1- Zang Wenqiao College of Basic Medical Sciences, Zhengzhou University, No. 100 Kexue Road, 450001, Zhengzhou, China aut NATIONALLICENCE 700 1- Wang Yuanyuan College of Basic Medical Sciences, Zhengzhou University, No. 100 Kexue Road, 450001, Zhengzhou, China aut NATIONALLICENCE 700 1- Chen Xiaonan College of Basic Medical Sciences, Zhengzhou University, No. 100 Kexue Road, 450001, Zhengzhou, China aut NATIONALLICENCE 700 1- Li Min College of Basic Medical Sciences, Zhengzhou University, No. 100 Kexue Road, 450001, Zhengzhou, China aut NATIONALLICENCE 700 1- Zhao Guoqiang College of Basic Medical Sciences, Zhengzhou University, No. 100 Kexue Road, 450001, Zhengzhou, China aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 404/1-2(2015-06-01), 31-38 0300-8177 404:1-2<31 2015 404 11010