caa a22 4500 606233776 CHVBK 20210128101234.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s11010-015-2373-7 doi (NATIONALLICENCE)springer-10.1007/s11010-015-2373-7 The E23K and A190A variations of the KCNJ11 gene are associated with early-onset type 2 diabetes and blood pressure in the Chinese population [Elektronische Daten] [Langen Zhuang, Yu Zhao, Weijing Zhao, Ming Li, Ming Yu, Ming Lu, Rong Zhang, Xiaoxu Ge, Taishan Zheng, Can Li, Jun Yin, Jingyuan Yin, Yuqian Bao, Limei Liu, Weiping Jia, Yanjun Liu] Conflicting associations between define (KCNJ11) variations and susceptibility to late-onset (>40years old) type 2 diabetes mellitus (T2DM) have been reported in different ethnic groups. We investigated whether the E23K (G→A, rs5219) or A190A (C→T, rs5218) variations in KCNJ11 are associated with early-onset T2DM and blood pressure in the Chinese population. Case-control study of 175 unrelated Chinese patients with early-onset T2DM (age of onset <40years old) who receive (ins+, n=57) or do not receive insulin (ins−, n=118), and 182 non-diabetic control subjects. PCR-direct sequencing was performed to genotype E23K and A190A; the genotypic frequencies and associations with clinical characteristics were analyzed. The genotypic frequencies of E23K-GA+AA were higher and A190A-TT was lower in the early-onset T2DM group, especially the T2D-ins+ group, compared to the non-diabetic control group (p<0.01 or 0.05, respectively). In non-diabetic subjects, E23K-AA carriers had significantly higher 2h plasma glucose and lower 2h insulin than E23K-GG carriers (both p<0.05). A190A-TT or E23K-GG carriers had higher systolic blood pressure (SBP) than CC or AA carriers in the non-diabetic control and T2DM groups (both p<0.05). In the T2DM ins+ group, E23K-AA carriers had lower onset age and duration of diabetes and higher BMI than GG carriers, and A190A-TT carriers had higher SBP than CC carriers (all p<0.05). The E23K-GA or AA genotypes may increase the susceptibility to early-onset T2DM, while A190A-TT may protect against early-onset T2DM. On the other hand the A190A-TT or E23K-GG genotypes may increase the risk of hypertension in the Chinese population. Springer Science+Business Media New York, 2015 KCNJ11 nationallicence E23K nationallicence A190A nationallicence Early-onset type 2 diabetes nationallicence Systolic blood pressure (SBP) nationallicence Zhuang Langen Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut Zhao Yu Department of Endocrinology, Inner Mongolia General Forestry Hospital, Yakeshi, Inner Mongolia, China aut Zhao Weijing Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut Li Ming Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut Yu Ming Department of Endocrinology & Metabolism, Putuo Hospital Attached to Shanghai University of Traditional Chinese Medicine, Shanghai, China aut Lu Ming Department of Endocrinology & Metabolism, Putuo Hospital Attached to Shanghai University of Traditional Chinese Medicine, Shanghai, China aut Zhang Rong Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut Ge Xiaoxu Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut Zheng Taishan Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut Li Can Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut Yin Jun Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut Yin Jingyuan School of Computer Engineering and Science, Shanghai University, Shanghai, China aut Bao Yuqian Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut Liu Limei Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut Jia Weiping Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut Liu Yanjun Division of Endocrinology, UCLA School of Medicine, Charles R. Drew University of Medicine & Sciences, Los Angeles, CA, USA aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 404/1-2(2015-06-01), 133-141 0300-8177 404:1-2<133 2015 404 11010 https://doi.org/10.1007/s11010-015-2373-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-015-2373-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhuang Langen Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut NATIONALLICENCE 700 1- Zhao Yu Department of Endocrinology, Inner Mongolia General Forestry Hospital, Yakeshi, Inner Mongolia, China aut NATIONALLICENCE 700 1- Zhao Weijing Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut NATIONALLICENCE 700 1- Li Ming Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut NATIONALLICENCE 700 1- Yu Ming Department of Endocrinology & Metabolism, Putuo Hospital Attached to Shanghai University of Traditional Chinese Medicine, Shanghai, China aut NATIONALLICENCE 700 1- Lu Ming Department of Endocrinology & Metabolism, Putuo Hospital Attached to Shanghai University of Traditional Chinese Medicine, Shanghai, China aut NATIONALLICENCE 700 1- Zhang Rong Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut NATIONALLICENCE 700 1- Ge Xiaoxu Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut NATIONALLICENCE 700 1- Zheng Taishan Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut NATIONALLICENCE 700 1- Li Can Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut NATIONALLICENCE 700 1- Yin Jun Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut NATIONALLICENCE 700 1- Yin Jingyuan School of Computer Engineering and Science, Shanghai University, Shanghai, China aut NATIONALLICENCE 700 1- Bao Yuqian Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut NATIONALLICENCE 700 1- Liu Limei Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut NATIONALLICENCE 700 1- Jia Weiping Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, 200233, Shanghai, China aut NATIONALLICENCE 700 1- Liu Yanjun Division of Endocrinology, UCLA School of Medicine, Charles R. Drew University of Medicine & Sciences, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 404/1-2(2015-06-01), 133-141 0300-8177 404:1-2<133 2015 404 11010