caa a22 4500 606233806 CHVBK 20210128101234.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s11010-015-2376-4 doi (NATIONALLICENCE)springer-10.1007/s11010-015-2376-4 Overexpression of ADAMTS-7 leads to accelerated initiation and progression of collagen-induced arthritis in mice [Elektronische Daten] [Yuying Zhang, Fanhua Wei, Chuan-ju Liu] The aim of the present study is to determine whether ADAMTS-7 contributes to the onset and severity of joint inflammation in the pathogenesis of inflammatory arthritis. ADAMTS-7 was found to be elevated in the course of collagen-induced arthritis (CIA). ADAMTS-7 transgenic (TG) mice were more susceptible to the induction of CIA. The onset of CIA was accelerated and the arthritic severity was increased in TG mice compared to wild-type mice. The overall incidence was also significantly higher in TG mice. In addition, arthritic TG mice displayed significantly higher clinical and histological arthritis scores. The COMP degradative fragments were significantly elevated in articular cartilage and sera in CIA models of TG mice. Furthermore, the production of tumor necrosis factor-alpha and interleukin-17 was also increased in serum and draining lymph nodes of arthritic TG mice. Therefore, these data provided the in vivo evidence, suggesting that ADAMTS-7 may play an important role in the pathogenesis of inflammatory arthritis, and that inhibition of ADAMTS-7 may be a potential target to ameliorate the severity of inflammatory arthritis. Springer Science+Business Media New York, 2015 ADAMTS-7 nationallicence COMP nationallicence Transgenic mice nationallicence Collagen-induced arthritis nationallicence TNF-α nationallicence Zhang Yuying Department of Orthopaedic Surgery, New York University Medical Center, Rm 1608, HJD, 301 East 17th Street, 10003, New York, NY, USA aut Wei Fanhua Department of Orthopaedic Surgery, New York University Medical Center, Rm 1608, HJD, 301 East 17th Street, 10003, New York, NY, USA aut Liu Chuan-ju Department of Orthopaedic Surgery, New York University Medical Center, Rm 1608, HJD, 301 East 17th Street, 10003, New York, NY, USA aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 404/1-2(2015-06-01), 171-179 0300-8177 404:1-2<171 2015 404 11010 https://doi.org/10.1007/s11010-015-2376-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-015-2376-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhang Yuying Department of Orthopaedic Surgery, New York University Medical Center, Rm 1608, HJD, 301 East 17th Street, 10003, New York, NY, USA aut NATIONALLICENCE 700 1- Wei Fanhua Department of Orthopaedic Surgery, New York University Medical Center, Rm 1608, HJD, 301 East 17th Street, 10003, New York, NY, USA aut NATIONALLICENCE 700 1- Liu Chuan-ju Department of Orthopaedic Surgery, New York University Medical Center, Rm 1608, HJD, 301 East 17th Street, 10003, New York, NY, USA aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 404/1-2(2015-06-01), 171-179 0300-8177 404:1-2<171 2015 404 11010