caa a22 4500 606234039 CHVBK 20210128101235.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s11010-014-2316-8 doi (NATIONALLICENCE)springer-10.1007/s11010-014-2316-8 Anti-tumor properties of cis -resveratrol methylated analogs in metastatic mouse melanoma cells [Elektronische Daten] [Valery Morris, Tayyaba Toseef, Fathima Nazumudeen, Christian Rivoira, Carmela Spatafora, Corrado Tringali, Susan Rotenberg] Resveratrol (E-3,5,4′-trihydroxystilbene) is a polyphenol found in red wine that has been shown to have multiple anti-cancer properties. Although cis-(Z)- and trans-(E)-isomers of resveratrol occur in nature, the cis form is not biologically active. However, methylation at key positions of the cis form results in more potent anti-cancer properties. This study determined that synthetic cis-polymethoxystilbenes (methylated analogs of cis-resveratrol) inhibited cancer-related phenotypes of metastatic B16 F10 and non-metastatic B16 F1 mouse melanoma cells. In contrast with cis- or trans-resveratrol and trans-polymethoxystilbene which were ineffective at 10μM, cis-polymethoxystilbenes inhibited motility and proliferation of melanoma cells with low micromolar specificity (IC50<10μM). Inhibitory effects by cis-polymethoxystilbenes were significantly stronger with B16 F10 cells and were accompanied by decreased expression of β-tubulin and pleckstrin homology domain-interacting protein, a marker of metastatic B16 cells. Thus, cis-polymethoxystilbenes have potential as chemotherapeutic agents for metastatic melanoma. Springer Science+Business Media New York, 2015 Polymethoxystilbenes nationallicence Cell motility nationallicence Proliferation nationallicence β-tubulin nationallicence PHIP nationallicence Anti-cancer nationallicence Morris Valery Department of Chemistry and Biochemistry, Queens College of the City University of New York, Flushing, NY, USA aut Toseef Tayyaba Department of Chemistry and Biochemistry, Queens College of the City University of New York, Flushing, NY, USA aut Nazumudeen Fathima Department of Chemistry and Biochemistry, Queens College of the City University of New York, Flushing, NY, USA aut Rivoira Christian Department of Chemistry and Biochemistry, Queens College of the City University of New York, Flushing, NY, USA aut Spatafora Carmela Dipartimento di Scienze Chimiche, Università di Catania, Catania, Italy aut Tringali Corrado Dipartimento di Scienze Chimiche, Università di Catania, Catania, Italy aut Rotenberg Susan Department of Chemistry and Biochemistry, Queens College of the City University of New York, Flushing, NY, USA aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 402/1-2(2015-04-01), 83-91 0300-8177 402:1-2<83 2015 402 11010 https://doi.org/10.1007/s11010-014-2316-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-014-2316-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morris Valery Department of Chemistry and Biochemistry, Queens College of the City University of New York, Flushing, NY, USA aut NATIONALLICENCE 700 1- Toseef Tayyaba Department of Chemistry and Biochemistry, Queens College of the City University of New York, Flushing, NY, USA aut NATIONALLICENCE 700 1- Nazumudeen Fathima Department of Chemistry and Biochemistry, Queens College of the City University of New York, Flushing, NY, USA aut NATIONALLICENCE 700 1- Rivoira Christian Department of Chemistry and Biochemistry, Queens College of the City University of New York, Flushing, NY, USA aut NATIONALLICENCE 700 1- Spatafora Carmela Dipartimento di Scienze Chimiche, Università di Catania, Catania, Italy aut NATIONALLICENCE 700 1- Tringali Corrado Dipartimento di Scienze Chimiche, Università di Catania, Catania, Italy aut NATIONALLICENCE 700 1- Rotenberg Susan Department of Chemistry and Biochemistry, Queens College of the City University of New York, Flushing, NY, USA aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 402/1-2(2015-04-01), 83-91 0300-8177 402:1-2<83 2015 402 11010