caa a22 4500 606234047 CHVBK 20210128101235.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s11010-014-2325-7 doi (NATIONALLICENCE)springer-10.1007/s11010-014-2325-7 Spleen-specific isoforms of Pax5 and Ataxin-7 as potential proteomic markers of lymphoma-affected spleen [Elektronische Daten] [Brij Bharti, Rajnikant Mishra] The splenomegaly, enlargement of spleen, has been observed in several diseases. It has been intended to evaluate histochemical alterations, spleen-specific enzymatic and proteomic markers during splenomegaly, and lympho-proliferative disorders from spleen of mice bearing Dalton's lymphoma. The higher expression of c-fos, c-jun, and MAPK testifies proliferation of lymphocytes. The lower expression of Pax5, higher expression of CD3, and the presence of additional form of Zap-70 suggest hypertrophy of follicles and splenomegaly influenced by weak B-cell receptor-mediated signaling, but activated T-cell receptor-mediated signaling. Simultaneously, lower levels of SOD, NDR2, and MIB2 and higher expression levels of Ataxin-7 and LDH also suggest impact of stress either as a cause or effect of cell proliferation. Spleen-specific isoform of Pax5, NDR2, MIB2, and Ataxin-7 can be considered as spleen-specific unique molecular markers for the evaluation of splenomegaly and lympho-proliferative disorders. Springer Science+Business Media New York, 2015 Splenomegaly nationallicence Lympho-proliferative disorders nationallicence Pax-5 nationallicence NDR2 nationallicence MIB2 nationallicence Ataxin-7 nationallicence Bharti Brij Department of Zoology, Banaras Hindu University, 221005, Varanasi, India aut Mishra Rajnikant Department of Zoology, Banaras Hindu University, 221005, Varanasi, India aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 402/1-2(2015-04-01), 181-191 0300-8177 402:1-2<181 2015 402 11010 https://doi.org/10.1007/s11010-014-2325-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-014-2325-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bharti Brij Department of Zoology, Banaras Hindu University, 221005, Varanasi, India aut NATIONALLICENCE 700 1- Mishra Rajnikant Department of Zoology, Banaras Hindu University, 221005, Varanasi, India aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 402/1-2(2015-04-01), 181-191 0300-8177 402:1-2<181 2015 402 11010