caa a22 4500 606234071 CHVBK 20210128101235.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s11010-014-2250-9 doi (NATIONALLICENCE)springer-10.1007/s11010-014-2250-9 Effects of celecoxib and ibuprofen on metabolic disorders induced by Walker-256 tumor in rats [Elektronische Daten] [Camila de Souza, Mirian Kurauti, Flaviane de Fatima Silva, Hely de Morais, Glaucia Borba-Murad, Fábio de Andrade, Helenir de Souza] The contribution of anti-inflammatory property of celecoxib in the improvement of metabolic disorders in cancer is unknown. The purpose of this study was to compare the effects of celecoxib and ibuprofen, non-steroidal anti-inflammatory drugs (NSAIDs), on several metabolic changes observed in Walker-256 tumor-bearing rats. The effects of these NSAIDs on the tumor growth were also assessed. Celecoxib or ibuprofen (both at 25mg/Kg) was administered orally for 12days, beginning on the day the rats were inoculated with Walker-256 tumor cells. Celecoxib treatment prevented the losses in body mass and mass of retroperitoneal adipose tissue, gastrocnemius, and extensor digitorum longus muscles in tumor-bearing rats. Celecoxib also prevented the rise in blood levels of triacylglycerol, urea, and lactate, the inhibition of peripheral response to insulin and hepatic glycolysis, and tended to attenuate the decrease in the food intake, but had no effect on the reduction of glycemia induced by the tumor. In addition, celecoxib treatment increased the number of Walker-256 cells with signs of apoptosis and the tumor necrosis area and prevented the tumor growth. In contrast, ibuprofen treatment had no effect on metabolic parameters affected by the Walker-256 tumor or tumor growth. It can be concluded that celecoxib, unlike ibuprofen, ameliorated several metabolic changes in rats with Walker-256 tumor due to its anti-tumor effect and not its anti-inflammatory property. Springer Science+Business Media New York, 2014 Cancer nationallicence Non-steroidal anti-inflammatory drugs nationallicence Cachexia nationallicence Blood metabolic parameters nationallicence Insulin resistance nationallicence Hepatic glycolysis nationallicence de Souza Camila Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil aut Kurauti Mirian Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil aut de Fatima Silva Flaviane Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil aut de Morais Hely Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil aut Borba-Murad Glaucia Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil aut de Andrade Fábio Department of Histology, State University of Londrina, 86051-990, Londrina, PR, Brazil aut de Souza Helenir Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 399/1-2(2015-01-01), 237-246 0300-8177 399:1-2<237 2015 399 11010 https://doi.org/10.1007/s11010-014-2250-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-014-2250-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- de Souza Camila Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil aut NATIONALLICENCE 700 1- Kurauti Mirian Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil aut NATIONALLICENCE 700 1- de Fatima Silva Flaviane Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil aut NATIONALLICENCE 700 1- de Morais Hely Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil aut NATIONALLICENCE 700 1- Borba-Murad Glaucia Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil aut NATIONALLICENCE 700 1- de Andrade Fábio Department of Histology, State University of Londrina, 86051-990, Londrina, PR, Brazil aut NATIONALLICENCE 700 1- de Souza Helenir Department of Physiological Sciences, State University of Londrina, 86051-990, Londrina, PR, Brazil aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 399/1-2(2015-01-01), 237-246 0300-8177 399:1-2<237 2015 399 11010