caa a22 4500 606234268 CHVBK 20210128101236.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s11010-014-2233-x doi (NATIONALLICENCE)springer-10.1007/s11010-014-2233-x Low glucose transporter SLC2A5 -inhibited human normal adjacent lung adenocarcinoma cytoplasmic pro-B cell development mechanism network [Elektronische Daten] [Jingwen You, Lin Wang, Juxiang Huang, Minghu Jiang, Qingchun Chen, Yangming Wang, Zhenfu Jiang] Solute carrier family 2 (facilitated glucose/fructose transporter) member 5 (SLC2A5)-inhibited seven different molecular Pearson mutual-positive-correlation networks constructed by 24 overlapping molecules from 368 GRNInfer and 34 Pearson under SLC2A5 CC ≤−0.25 in low human normal adjacent tissues were compared with high lung adenocarcinoma. Based on GO, KEGG, GenMAPP, BioCarta, and disease databases, our result showed that low SLC2A5-inhibited network included Golgi apparatus of AP1M2_1; cell cycle of CUL7, SAC3D1; protein amino acid dephosphorylation of STYXL1; pro-B cell-cell differentiation of SOX4_3; and FAD biosynthesis of FLAD1. Thus, we propose low glucose transporter SLC2A5-inhibited human normal adjacent lung adenocarcinoma cytoplasmic pro-B cell development mechanism network through repression of protein amino acid dephosphorylation to FAD biosynthesis. Springer Science+Business Media New York, 2014 Low glucose transporter SLC2A5 nationallicence Cytoplasmic pro-B cell development repression nationallicence Mechanism nationallicence Human normal adjacent lung adenocarcinoma nationallicence You Jingwen Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, 100876, Beijing, China aut Wang Lin Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, 100876, Beijing, China aut Huang Juxiang Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, 100876, Beijing, China aut Jiang Minghu Lab of Computational Linguistics, School of Humanities and Social Sciences, Tsinghua University, 100084, Beijing, China aut Chen Qingchun Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, 100876, Beijing, China aut Wang Yangming Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, 100876, Beijing, China aut Jiang Zhenfu Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, 100876, Beijing, China aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 399/1-2(2015-01-01), 71-76 0300-8177 399:1-2<71 2015 399 11010 https://doi.org/10.1007/s11010-014-2233-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 brief-communication jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-014-2233-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- You Jingwen Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, 100876, Beijing, China aut NATIONALLICENCE 700 1- Wang Lin Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, 100876, Beijing, China aut NATIONALLICENCE 700 1- Huang Juxiang Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, 100876, Beijing, China aut NATIONALLICENCE 700 1- Jiang Minghu Lab of Computational Linguistics, School of Humanities and Social Sciences, Tsinghua University, 100084, Beijing, China aut NATIONALLICENCE 700 1- Chen Qingchun Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, 100876, Beijing, China aut NATIONALLICENCE 700 1- Wang Yangming Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, 100876, Beijing, China aut NATIONALLICENCE 700 1- Jiang Zhenfu Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, 100876, Beijing, China aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 399/1-2(2015-01-01), 71-76 0300-8177 399:1-2<71 2015 399 11010