caa a22 4500 606234276 CHVBK 20210128101236.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s11010-014-2248-3 doi (NATIONALLICENCE)springer-10.1007/s11010-014-2248-3 Tannic acid mitigates the DMBA/croton oil-induced skin cancer progression in mice [Elektronische Daten] [Ferial Majed, Summya Rashid, Abdul Khan, Sana Nafees, Nemat Ali, Rashid Ali, Rehan Khan, Syed Hasan, Syed Mehdi, Sarwat Sultana] Skin cancer is the most common malignancy in the world and also one of the major causes of death worldwide. The toxic environmental pollutant 7,12-dimethylbenz[a]anthracene (DMBA) is a skin-specific carcinogen. Tannic acid (TA) is reported to be effective against various types of chemical-induced toxicities and carcinogenesis as well. In the present study, we have evaluated the therapeutic potential of tannic acid in DMBA+croton oil-induced skin cancer in Swiss albino mice. Protective effect of TA against skin cancer was evaluated in terms of antioxidant enzymes activities, lipid peroxidation, histopathological changes and expression of inflammation and early tumour markers. DMBA+croton oil causes depletion of antioxidant enzymes (p<0.001) and elevation of early inflammatory and tumour promotional events. TA prevents the DMBA+croton oil-induced toxicity through a protective mechanism that involves the reduction of oxidative stress as well as COX-2, i-NOS, PCNA protein expression and level of proinflammatory cytokine such as IL-6 release at a very significant level (p<0.001). It could be concluded from our results that TA attenuates DMBA+croton oil-induced tumour promotional potential possibly by inhibiting oxidative and inflammatory responses and acts as antioxidant, anti-inflammatory and antiproliferative agent. Springer Science+Business Media New York, 2014 Oxidative stress nationallicence Inflammation nationallicence Tannic acid nationallicence Skin cancer nationallicence DMBA nationallicence Croton oil nationallicence Majed Ferial Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut Rashid Summya Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut Khan Abdul Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut Nafees Sana Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut Ali Nemat Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut Ali Rashid Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut Khan Rehan Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut Hasan Syed Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut Mehdi Syed Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut Sultana Sarwat Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 399/1-2(2015-01-01), 217-228 0300-8177 399:1-2<217 2015 399 11010 https://doi.org/10.1007/s11010-014-2248-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-014-2248-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Majed Ferial Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut NATIONALLICENCE 700 1- Rashid Summya Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut NATIONALLICENCE 700 1- Khan Abdul Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut NATIONALLICENCE 700 1- Nafees Sana Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut NATIONALLICENCE 700 1- Ali Nemat Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut NATIONALLICENCE 700 1- Ali Rashid Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut NATIONALLICENCE 700 1- Khan Rehan Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut NATIONALLICENCE 700 1- Hasan Syed Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut NATIONALLICENCE 700 1- Mehdi Syed Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut NATIONALLICENCE 700 1- Sultana Sarwat Section of Molecular Carcinogenesis and Chemoprevention, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard (Hamdard University), Hamdard Nagar, 110062, New Delhi, India aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 399/1-2(2015-01-01), 217-228 0300-8177 399:1-2<217 2015 399 11010