caa a22 4500 606234969 CHVBK 20210128101240.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s11010-014-2203-3 doi (NATIONALLICENCE)springer-10.1007/s11010-014-2203-3 Effect of geraniol, a plant derived monoterpene on lipids and lipid metabolizing enzymes in experimental hyperlipidemic hamsters [Elektronische Daten] [Muthukumaran Jayachandran, Balaji Chandrasekaran, Nalini Namasivayam] Hyperlipidemia is a major, modifiable risk factor for atherosclerosis and cardiovascular disease. In the present study, we have focused on the effect of different doses of geraniol (GOH) on the lipid profile and lipid metabolizing enzymes in atherogenic diet (AD) fed hamsters. Male Syrian hamsters were grouped into seven: group 1 were control animals; group 2 were animals fed GOH alone (200mg/kg b.w); group 3 were animals fed AD (10% coconut oil, 0.25% cholesterol, and 0.25% cholic acid); group 4 were animals fed AD+corn oil (2.5ml/kg b.w); and groups 5, 6, and 7 were fed AD as in group 3+different doses of GOH (50, 100, and 200mg/kg b.w), respectively, for 12weeks. At the end of the experimental period, animals were sacrificed by cervical dislocation and various assays were performed in the plasma and tissues. The AD hamsters showed marked changes in lipid profile and lipid metabolizing enzymes. However, supplementation with GOH counteracted the hyperlipidemia by inhibiting HMG CoA reductase and suppressing lipogenesis. The antihyperlipidemic efficacy of GOH was found to be effective at the dose of 100mg/kg b.w. This study illustrates that GOH is effective in lowering the risk of hyperlipidemia in AD fed hamsters. Springer Science+Business Media New York, 2014 Atherosclerosis nationallicence Hyperlipidemia nationallicence Atherogenic diet nationallicence Lipid profile nationallicence Lipid metabolizing enzymes nationallicence Geraniol nationallicence Jayachandran Muthukumaran Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, 608002, Annamalainagar, Tamilnadu, India aut Chandrasekaran Balaji Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, 608002, Annamalainagar, Tamilnadu, India aut Namasivayam Nalini Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, 608002, Annamalainagar, Tamilnadu, India aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 398/1-2(2015-01-01), 39-53 0300-8177 398:1-2<39 2015 398 11010 https://doi.org/10.1007/s11010-014-2203-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-014-2203-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jayachandran Muthukumaran Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, 608002, Annamalainagar, Tamilnadu, India aut NATIONALLICENCE 700 1- Chandrasekaran Balaji Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, 608002, Annamalainagar, Tamilnadu, India aut NATIONALLICENCE 700 1- Namasivayam Nalini Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, 608002, Annamalainagar, Tamilnadu, India aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 398/1-2(2015-01-01), 39-53 0300-8177 398:1-2<39 2015 398 11010