caa a22 4500 606235043 CHVBK 20210128101240.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s11010-014-2211-3 doi (NATIONALLICENCE)springer-10.1007/s11010-014-2211-3 miR-338 suppresses the growth and metastasis of OSCC cells by targeting NRP1 [Elektronische Daten] [Chunxi Liu, Zhiyu Wang, Yi Wang, Wuwei Gu] microRNAs (miRNAs) are small non-coding RNAs that have been suggested to play an essential role in tumorigenesis. Reduced expression of miR-338 has been reported in several types of cancers; however, the role of miR-338 in oral squamous cell carcinoma (OSCC) has not been elucidated. In this study, we demonstrated that miR-338 was dramatically downregulated in OSCC tissues and cell lines. Overexpression of miR-338 significantly inhibited proliferation, colony formation, migration, and invasion of OSCC cells. In addition, neuropilin1 (NRP1) was identified as a target of miR-338 in OSCC cells and inversely correlated with miR-338 in OSCC tissues. Furthermore, restoration of NRP1 attenuated the tumor-suppressive effects of miR-338. Taken together, miR-338 might inhibit growth and metastasis of OSCC cells by targeting NRP1. Springer Science+Business Media New York, 2014 Oral squamous cell carcinoma nationallicence miR-338 nationallicence Neuropilin1 nationallicence Growth nationallicence Metastasis nationallicence Liu Chunxi Department of Stomatology, Xi'an No.4 Hospital (The Affiliated Guangren Hospital of Xi'an Jiaotong University College Medicine), 710004, Xi'an, China aut Wang Zhiyu Department of Stomatology, Hospital of Xi'an Jiaotong University, 710049, Xi'an, China aut Wang Yi Department of Stomatology, Xi'an No.4 Hospital (The Affiliated Guangren Hospital of Xi'an Jiaotong University College Medicine), 710004, Xi'an, China aut Gu Wuwei Department of Stomatology, Xi'an No.4 Hospital (The Affiliated Guangren Hospital of Xi'an Jiaotong University College Medicine), 710004, Xi'an, China aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 398/1-2(2015-01-01), 115-122 0300-8177 398:1-2<115 2015 398 11010 https://doi.org/10.1007/s11010-014-2211-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-014-2211-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Chunxi Department of Stomatology, Xi'an No.4 Hospital (The Affiliated Guangren Hospital of Xi'an Jiaotong University College Medicine), 710004, Xi'an, China aut NATIONALLICENCE 700 1- Wang Zhiyu Department of Stomatology, Hospital of Xi'an Jiaotong University, 710049, Xi'an, China aut NATIONALLICENCE 700 1- Wang Yi Department of Stomatology, Xi'an No.4 Hospital (The Affiliated Guangren Hospital of Xi'an Jiaotong University College Medicine), 710004, Xi'an, China aut NATIONALLICENCE 700 1- Gu Wuwei Department of Stomatology, Xi'an No.4 Hospital (The Affiliated Guangren Hospital of Xi'an Jiaotong University College Medicine), 710004, Xi'an, China aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 398/1-2(2015-01-01), 115-122 0300-8177 398:1-2<115 2015 398 11010