caa a22 4500 606235132 CHVBK 20210128101241.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s11010-014-2201-5 doi (NATIONALLICENCE)springer-10.1007/s11010-014-2201-5 DNA-binding and cytotoxic efficacy studies of organorhenium pentylcarbonate compounds [Elektronische Daten] [Jewel Medley, Gloria Payne, Hirendra Banerjee, Dipak Giri, Angela Winstead, James Wachira, Jeanette Krause, Roosevelt Shaw, Saroj Pramanik, Santosh Mandal] Seven organorhenium pentylcarbonate compounds (PC1-PC7) have been synthesized. DNA-binding studies of the PC-series compounds using electronic spectroscopy and gel electrophoresis suggest that the compounds presumably bind to DNA in an intercalative mode. The intrinsic binding constants for PC4, PC6, and PC7 were found to be 1.6×104, 3.9×104, and 4.2×104M−1, respectively. The X-ray structure determinations and density functional theory calculations indicate that the polypyridyl ligands in the compounds are nearly planar facilitating DNA binding throughan intercalation mechanism. Cytotoxicity studies of 10µM pentylcarbonate compounds against HTB-12 human astrocytoma brain cancer cells were studied for 48h. It was observed that each of the pentylcarbonate compounds is active against the cancer cells. However, under analogous conditions, CRL-2005 rat astrocyte normal brain cells are not affected significantly. Springer Science+Business Media New York, 2014 Rhenium nationallicence DNA nationallicence X-rayCrytallography nationallicence Intercalation nationallicence Electronic spectroscopy nationallicence Brain cancer nationallicence Medley Jewel Department of Biology, Elizabeth City State University, 27909, Elizabeth City, NC, USA aut Payne Gloria Department of Biology, Elizabeth City State University, 27909, Elizabeth City, NC, USA aut Banerjee Hirendra Department of Biology, Elizabeth City State University, 27909, Elizabeth City, NC, USA aut Giri Dipak Department of Chemistry, Morgan State University, 21251, Baltimore, MD, USA aut Winstead Angela Department of Chemistry, Morgan State University, 21251, Baltimore, MD, USA aut Wachira James Department of Biology, Morgan State University, 21251, Baltimore, MD, USA aut Krause Jeanette Department of Chemistry, University of Cincinnati, 45221, Cincinnati, OH, USA aut Shaw Roosevelt Department of Chemistry, Morgan State University, 21251, Baltimore, MD, USA aut Pramanik Saroj Department of Biology, Morgan State University, 21251, Baltimore, MD, USA aut Mandal Santosh Department of Chemistry, Morgan State University, 21251, Baltimore, MD, USA aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 398/1-2(2015-01-01), 21-30 0300-8177 398:1-2<21 2015 398 11010 https://doi.org/10.1007/s11010-014-2201-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-014-2201-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Medley Jewel Department of Biology, Elizabeth City State University, 27909, Elizabeth City, NC, USA aut NATIONALLICENCE 700 1- Payne Gloria Department of Biology, Elizabeth City State University, 27909, Elizabeth City, NC, USA aut NATIONALLICENCE 700 1- Banerjee Hirendra Department of Biology, Elizabeth City State University, 27909, Elizabeth City, NC, USA aut NATIONALLICENCE 700 1- Giri Dipak Department of Chemistry, Morgan State University, 21251, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Winstead Angela Department of Chemistry, Morgan State University, 21251, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Wachira James Department of Biology, Morgan State University, 21251, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Krause Jeanette Department of Chemistry, University of Cincinnati, 45221, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Shaw Roosevelt Department of Chemistry, Morgan State University, 21251, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Pramanik Saroj Department of Biology, Morgan State University, 21251, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Mandal Santosh Department of Chemistry, Morgan State University, 21251, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 398/1-2(2015-01-01), 21-30 0300-8177 398:1-2<21 2015 398 11010