caa a22 4500 606235280 CHVBK 20210128101241.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s11010-015-2496-x doi (NATIONALLICENCE)springer-10.1007/s11010-015-2496-x Derlin-1 is overexpressed in human colon cancer and promotes cancer cell proliferation [Elektronische Daten] [Xueming Tan, Xiaolu He, Zhonghua Jiang, Xiaohong Wang, Limei Ma, Li Liu, Xiang Wang, Zhining Fan, Dongming Su] Derlin-1 is overexpressed in many types of solid tumors and plays an important role in cancer progression. However, the expression pattern and functions of Derlin-1 in human colon cancer are not fully understood. In the present study, we examined Derlin-1 expression in colon cancer cell lines and human tissues and investigated its role in colon cancer. We found that Derlin-1 expression was increased significantly in colon cancer tissues and its overexpression correlated with the tumor differentiation, Dukes stage, invasion, lymph node metastasis, distant metastasis, and poor overall survival. The silencing of Derlin-1 by shRNA led to the growth inhibition of colon cancer cells, which were associated with the promotion of apoptosis. Furthermore, Derlin-1 silencing significantly inhibited the activation of the PI3K/AKT signaling pathway. Taken together, our results showed that Derlin-1 is overexpressed in colon cancer and promotes proliferation of colon cancer cells. Derlin-1 may be a potential therapeutic target for the treatment of colon cancer. Springer Science+Business Media New York, 2015 Derlin-1 nationallicence Human colon cancer nationallicence Proliferation nationallicence Apoptosis nationallicence ER : Endoplasmic reticulum nationallicence NSCLC : Non-small cell lung cancer nationallicence UPR : Unfolded protein response nationallicence Tan Xueming Department of Gastroenterology, Nanjing Dachang Hospital, 68 Taizishan Rd, Yanjiang Industrial Development Zone, 210044, Nanjing, Jiangsu, China aut He Xiaolu Department of Apheresis, Nanjing Red Cross Blood Center, 3 Zizhulin, 210003, Nanjing, Jiangsu, China aut Jiang Zhonghua Department of Gastroenterology, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan, 210011, Nanjing, Jiangsu, China aut Wang Xiaohong Department of Gastroenterology, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan, 210011, Nanjing, Jiangsu, China aut Ma Limei Department of Gastroenterology, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan, 210011, Nanjing, Jiangsu, China aut Liu Li Department of Endoscopy Center, The First Affiliated of Hospital of Nanjing Medical University, 300 Guangzhou St., 210029, Nanjing, Jiangsu, China aut Wang Xiang Department of Endoscopy Center, The First Affiliated of Hospital of Nanjing Medical University, 300 Guangzhou St., 210029, Nanjing, Jiangsu, China aut Fan Zhining Department of Endoscopy Center, The First Affiliated of Hospital of Nanjing Medical University, 300 Guangzhou St., 210029, Nanjing, Jiangsu, China aut Su Dongming The Metabolic Disease Research Centre, Nanjing Medical University, 140 Hanzhong St., 210029, Nanjing, Jiangsu, China aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 408/1-2(2015-10-01), 205-213 0300-8177 408:1-2<205 2015 408 11010 https://doi.org/10.1007/s11010-015-2496-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-015-2496-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tan Xueming Department of Gastroenterology, Nanjing Dachang Hospital, 68 Taizishan Rd, Yanjiang Industrial Development Zone, 210044, Nanjing, Jiangsu, China aut NATIONALLICENCE 700 1- He Xiaolu Department of Apheresis, Nanjing Red Cross Blood Center, 3 Zizhulin, 210003, Nanjing, Jiangsu, China aut NATIONALLICENCE 700 1- Jiang Zhonghua Department of Gastroenterology, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan, 210011, Nanjing, Jiangsu, China aut NATIONALLICENCE 700 1- Wang Xiaohong Department of Gastroenterology, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan, 210011, Nanjing, Jiangsu, China aut NATIONALLICENCE 700 1- Ma Limei Department of Gastroenterology, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjiayuan, 210011, Nanjing, Jiangsu, China aut NATIONALLICENCE 700 1- Liu Li Department of Endoscopy Center, The First Affiliated of Hospital of Nanjing Medical University, 300 Guangzhou St., 210029, Nanjing, Jiangsu, China aut NATIONALLICENCE 700 1- Wang Xiang Department of Endoscopy Center, The First Affiliated of Hospital of Nanjing Medical University, 300 Guangzhou St., 210029, Nanjing, Jiangsu, China aut NATIONALLICENCE 700 1- Fan Zhining Department of Endoscopy Center, The First Affiliated of Hospital of Nanjing Medical University, 300 Guangzhou St., 210029, Nanjing, Jiangsu, China aut NATIONALLICENCE 700 1- Su Dongming The Metabolic Disease Research Centre, Nanjing Medical University, 140 Hanzhong St., 210029, Nanjing, Jiangsu, China aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 408/1-2(2015-10-01), 205-213 0300-8177 408:1-2<205 2015 408 11010