caa a22 4500 606235515 CHVBK 20210128101243.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s11010-015-2464-5 doi (NATIONALLICENCE)springer-10.1007/s11010-015-2464-5 Kaempferol inhibits vascular smooth muscle cell migration by modulating BMP-mediated miR-21 expression [Elektronische Daten] [Kwangho Kim, Sunghwan Kim, Sang Moh, Hara Kang] Bioflavonoids are known to induce cardioprotective effects by inhibiting vascular smooth muscle cell (VSMC) proliferation and migration. Kaempferol has been shown to inhibit VSMC proliferation. However, little is known about the effect of kaempferol on VSMC migration and the underlying molecular mechanisms. Our studies provide the first evidence that kaempferol inhibits VSMC migration by modulating the BMP4 signaling pathway and microRNA expression levels. Kaempferol activates the BMP signaling pathway, induces miR-21 expression and downregulates DOCK4, 5, and 7, leading to inhibition of cell migration. Moreover, kaempferol antagonizes the PDGF-mediated pro-migratory effect. Therefore, our study uncovers a novel regulatory mechanism of VSMC migration by kaempferol and suggests that miRNA modulation by kaempferol is a potential therapy for cardiovascular diseases. Springer Science+Business Media New York, 2015 BMP nationallicence Vascular smooth muscle cells nationallicence microRNA-21 nationallicence Cell migration nationallicence Kaempferol nationallicence Kim Kwangho Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, 406-772, Incheon, Republic of Korea aut Kim Sunghwan New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 701-310, Daegu, Republic of Korea aut Moh Sang Antiaging Research Institute of BIO-FD&C Co. Ltd., 405-849, Incheon, Republic of Korea aut Kang Hara Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, 406-772, Incheon, Republic of Korea aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 407/1-2(2015-09-01), 143-149 0300-8177 407:1-2<143 2015 407 11010 https://doi.org/10.1007/s11010-015-2464-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-015-2464-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Kwangho Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, 406-772, Incheon, Republic of Korea aut NATIONALLICENCE 700 1- Kim Sunghwan New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, 701-310, Daegu, Republic of Korea aut NATIONALLICENCE 700 1- Moh Sang Antiaging Research Institute of BIO-FD&C Co. Ltd., 405-849, Incheon, Republic of Korea aut NATIONALLICENCE 700 1- Kang Hara Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, 406-772, Incheon, Republic of Korea aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 407/1-2(2015-09-01), 143-149 0300-8177 407:1-2<143 2015 407 11010