caa a22 4500 60623554X CHVBK 20210128101243.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s11010-015-2455-6 doi (NATIONALLICENCE)springer-10.1007/s11010-015-2455-6 miR-526a regulates apoptotic cell growth in human carcinoma cells [Elektronische Daten] [Xiaoli Yang, Cui Wang, Changzhi Xu, Zhifeng Yan, Congwen Wei, Kai Guan, Shengli Ma, Ye Cao, Liping Liu, Deyong Zou, Xiang He, Buchang Zhang, Qingjun Ma, Zirui Zheng] MicroRNAs (miRNAs) play vital roles in the regulation of cell cycle, cell growth, apoptosis, and tumorigenesis. Our previous studies showed that miR-526a positively regulated innate immune response by suppressing CYLD expression, however, the functional relevance of miR-526a expression and cell growth remains to be evaluated. In this study, miR-526a overexpression was found to promote cancer cell proliferation, migration, and anchor-independent colony formation. The molecular mechanism(s) of miR-526a-mediated growth stimulation is associated with rapid cell cycle progression and inhibition of cell apoptosis by targeting CYLD. Taken together, these results provide evidence to show the stimulatory role of miR-526a in tumor migration and invasion through modulation of the canonical NF-κB signaling pathway. Springer Science+Business Media New York, 2015 miR-526a nationallicence Cell growth nationallicence NF-κB nationallicence CYLD nationallicence Yang Xiaoli Beijing Institute of Biotechnology, 100850, Beijing, China aut Wang Cui The General Hospital of Chinese People's Armed Police Forces, 100039, Beijing, China aut Xu Changzhi Beijing Institute of Biotechnology, 100850, Beijing, China aut Yan Zhifeng Gynecology and Obstetrics Department of Chinese PLA General Hospital, 100853, Beijing, China aut Wei Congwen Beijing Institute of Biotechnology, 100850, Beijing, China aut Guan Kai Beijing Institute of Biotechnology, 100850, Beijing, China aut Ma Shengli Beijing Institute of Biotechnology, 100850, Beijing, China aut Cao Ye Beijing Institute of Biotechnology, 100850, Beijing, China aut Liu Liping The General Hospital of Chinese People's Armed Police Forces, 100039, Beijing, China aut Zou Deyong The General Hospital of Chinese People's Armed Police Forces, 100039, Beijing, China aut He Xiang Beijing Institute of Biotechnology, 100850, Beijing, China aut Zhang Buchang Institute of Health Science, School of Life Sciences, Anhui University, 230601, Hefei, Anhui, China aut Ma Qingjun Beijing Institute of Biotechnology, 100850, Beijing, China aut Zheng Zirui Beijing Institute of Biotechnology, 100850, Beijing, China aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 407/1-2(2015-09-01), 69-76 0300-8177 407:1-2<69 2015 407 11010 https://doi.org/10.1007/s11010-015-2455-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-015-2455-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang Xiaoli Beijing Institute of Biotechnology, 100850, Beijing, China aut NATIONALLICENCE 700 1- Wang Cui The General Hospital of Chinese People's Armed Police Forces, 100039, Beijing, China aut NATIONALLICENCE 700 1- Xu Changzhi Beijing Institute of Biotechnology, 100850, Beijing, China aut NATIONALLICENCE 700 1- Yan Zhifeng Gynecology and Obstetrics Department of Chinese PLA General Hospital, 100853, Beijing, China aut NATIONALLICENCE 700 1- Wei Congwen Beijing Institute of Biotechnology, 100850, Beijing, China aut NATIONALLICENCE 700 1- Guan Kai Beijing Institute of Biotechnology, 100850, Beijing, China aut NATIONALLICENCE 700 1- Ma Shengli Beijing Institute of Biotechnology, 100850, Beijing, China aut NATIONALLICENCE 700 1- Cao Ye Beijing Institute of Biotechnology, 100850, Beijing, China aut NATIONALLICENCE 700 1- Liu Liping The General Hospital of Chinese People's Armed Police Forces, 100039, Beijing, China aut NATIONALLICENCE 700 1- Zou Deyong The General Hospital of Chinese People's Armed Police Forces, 100039, Beijing, China aut NATIONALLICENCE 700 1- He Xiang Beijing Institute of Biotechnology, 100850, Beijing, China aut NATIONALLICENCE 700 1- Zhang Buchang Institute of Health Science, School of Life Sciences, Anhui University, 230601, Hefei, Anhui, China aut NATIONALLICENCE 700 1- Ma Qingjun Beijing Institute of Biotechnology, 100850, Beijing, China aut NATIONALLICENCE 700 1- Zheng Zirui Beijing Institute of Biotechnology, 100850, Beijing, China aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 407/1-2(2015-09-01), 69-76 0300-8177 407:1-2<69 2015 407 11010