caa a22 4500 606235752 CHVBK 20210128101244.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s11010-015-2465-4 doi (NATIONALLICENCE)springer-10.1007/s11010-015-2465-4 Low expression of dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin-related protein in lung cancer and significant correlations with brain metastasis and natural killer cells [Elektronische Daten] [Xiaoli Liu, Hua Zhang, Lijie Su, Peng Yang, Zhiqiang Xin, Junwei Zou, Shuangyi Ren, Yunfei Zuo] Dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin-related protein (DC-SIGNR) is a type II transmembrane protein which has been reported to bind a variety of pathogens as well as participate in immunoregulation. But the association between the level of DC-SIGNR and lung cancer is unknown. To investigate the clinical diagnostic significance of DC-SIGNR in lung cancer, we investigated serum DC-SIGNR levels in 173 lung cancer patients and 134 healthy individuals using enzyme-linked immunosorbent assay (ELISA). Results showed that serum DC-SIGNR levels in lung cancer patients were lower than that in healthy controls (P=0.0003). A cut-off value of 3.8998ng/L for DC-SIGNR predicted the presence of lung cancer with 78.03% sensitivity and 49.25% specificity (area under the curve=0.6212, P=0.0003). Strikingly, serum DC-SIGNR levels were significantly higher in lung cancer patients with brain metastasis compared to those without metastasis (P=0.0283). Moreover, the serum concentrations of DC-SIGNR in lung cancer patients also correlated significantly with serum natural killer cells percentage (P=0.0017). In addition, immunohistochemistry assay demonstrated that the expression of DC-SIGNR in lung tissues of 31 lung cancer patients and 13 tuberculosis patients was significantly lower than that in 18 normal lung tissues (P=0.0418, 0.0289), and there is no significant difference between tuberculosis tissues and lung cancer tissues (P=0.2696). These results suggest that DC-SIGNR maybe a promising biological molecule that has the potential for clinical research of lung cancer, whereas its underlying roles are needed to be investigated in further studies. Springer Science+Business Media New York, 2015 DC-SIGNR nationallicence Lung cancer nationallicence Expression nationallicence Brain metastasis nationallicence Natural killer cells nationallicence Liu Xiaoli Department of Clinical Biochemistry, College of Laboratory Diagnostic Medicine, Dalian Medical University, 116044, Dalian, China aut Zhang Hua Department of Clinical Biochemistry, College of Laboratory Diagnostic Medicine, Dalian Medical University, 116044, Dalian, China aut Su Lijie Department of Clinical Biochemistry, College of Laboratory Diagnostic Medicine, Dalian Medical University, 116044, Dalian, China aut Yang Peng Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, 116023, Dalian, China aut Xin Zhiqiang Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, 116023, Dalian, China aut Zou Junwei Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, 116023, Dalian, China aut Ren Shuangyi Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, 116023, Dalian, China aut Zuo Yunfei Department of Clinical Biochemistry, College of Laboratory Diagnostic Medicine, Dalian Medical University, 116044, Dalian, China aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 407/1-2(2015-09-01), 151-160 0300-8177 407:1-2<151 2015 407 11010 https://doi.org/10.1007/s11010-015-2465-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-015-2465-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Xiaoli Department of Clinical Biochemistry, College of Laboratory Diagnostic Medicine, Dalian Medical University, 116044, Dalian, China aut NATIONALLICENCE 700 1- Zhang Hua Department of Clinical Biochemistry, College of Laboratory Diagnostic Medicine, Dalian Medical University, 116044, Dalian, China aut NATIONALLICENCE 700 1- Su Lijie Department of Clinical Biochemistry, College of Laboratory Diagnostic Medicine, Dalian Medical University, 116044, Dalian, China aut NATIONALLICENCE 700 1- Yang Peng Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, 116023, Dalian, China aut NATIONALLICENCE 700 1- Xin Zhiqiang Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, 116023, Dalian, China aut NATIONALLICENCE 700 1- Zou Junwei Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, 116023, Dalian, China aut NATIONALLICENCE 700 1- Ren Shuangyi Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, 116023, Dalian, China aut NATIONALLICENCE 700 1- Zuo Yunfei Department of Clinical Biochemistry, College of Laboratory Diagnostic Medicine, Dalian Medical University, 116044, Dalian, China aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 407/1-2(2015-09-01), 151-160 0300-8177 407:1-2<151 2015 407 11010