caa a22 4500 606236147 CHVBK 20210128101246.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s11010-015-2430-2 doi (NATIONALLICENCE)springer-10.1007/s11010-015-2430-2 Oxidant/antioxidant effects of chronic exposure to predator odor in prefrontal cortex, amygdala, and hypothalamus [Elektronische Daten] [G. Mejia-Carmona, K. Gosselink, G. Pérez-Ishiwara, A. Martínez-Martínez] The incidence of anxiety-related diseases is increasing these days, hence there is a need to understand the mechanisms that underlie its nature and consequences. It is known that limbic structures, mainly the prefrontal cortex and amygdala, are involved in the processing of anxiety, and that projections from prefrontal cortex and amygdala can induce activity of the hypothalamic-pituitary-adrenal axis with consequent cardiovascular changes, increase in oxygen consumption, and ROS production. The compensatory reaction can include increased antioxidant enzymes activities, overexpression of antioxidant enzymes, and genetic shifts that could include the activation of antioxidant genes. The main objective of this study was to evaluate the oxidant/antioxidant effect that chronic anxiogenic stress exposure can have in prefrontal cortex, amygdala, and hypothalamus by exposition to predator odor. Results showed (a) sensitization of the HPA axis response, (b) an enzymatic phase 1 and 2 antioxidant response to oxidative stress in amygdala, (c) an antioxidant stability without elevation of oxidative markers in prefrontal cortex, (d) an elevation in phase 1 antioxidant response in hypothalamus. Chronic exposure to predator odor has an impact in the metabolic REDOX state in amygdala, prefrontal cortex, and hypothalamus, with oxidative stress being prevalent in amygdala as this is the principal structure responsible for the management of anxiety. The Author(s), 2015 Oxidative stress nationallicence Amygdala nationallicence Superoxide dismutase nationallicence Hypothalamus nationallicence Prefrontal cortex nationallicence Anxiogenic stress nationallicence Mejia-Carmona G. Departamento de Ciencias Químico Biológicas, Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo envolvente del Pronaf y Estocolmo S/N, Zona Pronaf, C.P. 32315, Ciudad Juárez, Chihuahua, Mexico aut Gosselink K. Department of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso, 500 W University Ave., 79902, El Paso, TX, USA aut Pérez-Ishiwara G. Instituto Politécnico Nacional, Escuela Nacional de Medicina y Homeopatía, Guillermo Massieu Helguera 239, Fracc. La Escalera, Ticomán, C.P. 07320, Mexico, Distrito Federal, Mexico aut Martínez-Martínez A. Departamento de Ciencias Químico Biológicas, Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo envolvente del Pronaf y Estocolmo S/N, Zona Pronaf, C.P. 32315, Ciudad Juárez, Chihuahua, Mexico aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 406/1-2(2015-08-01), 121-129 0300-8177 406:1-2<121 2015 406 11010 https://doi.org/10.1007/s11010-015-2430-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-015-2430-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mejia-Carmona G. Departamento de Ciencias Químico Biológicas, Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo envolvente del Pronaf y Estocolmo S/N, Zona Pronaf, C.P. 32315, Ciudad Juárez, Chihuahua, Mexico aut NATIONALLICENCE 700 1- Gosselink K. Department of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso, 500 W University Ave., 79902, El Paso, TX, USA aut NATIONALLICENCE 700 1- Pérez-Ishiwara G. Instituto Politécnico Nacional, Escuela Nacional de Medicina y Homeopatía, Guillermo Massieu Helguera 239, Fracc. La Escalera, Ticomán, C.P. 07320, Mexico, Distrito Federal, Mexico aut NATIONALLICENCE 700 1- Martínez-Martínez A. Departamento de Ciencias Químico Biológicas, Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Anillo envolvente del Pronaf y Estocolmo S/N, Zona Pronaf, C.P. 32315, Ciudad Juárez, Chihuahua, Mexico aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 406/1-2(2015-08-01), 121-129 0300-8177 406:1-2<121 2015 406 11010