caa a22 4500 606236163 CHVBK 20210128101246.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s11010-015-2425-z doi (NATIONALLICENCE)springer-10.1007/s11010-015-2425-z Redox status in acute ischemic stroke: correlation with clinical outcome [Elektronische Daten] [Dalibor Paspalj, Petar Nikic, Milan Savic, Dragan Djuric, Igor Simanic, Vladimir Zivkovic, Nevena Jeremic, Ivan Srejovic, Vladimir Jakovljevic] Connection between oxidative stress and clinical outcome in acute ischemic stroke (AIS) has been poorly investigated. This study was aimed to assess redox state (through measurement of oxidative stress markers) of patients with acute ischemic stroke during different stages of follow-up period, and to find association between values of mentioned markers and clinical outcome. The investigation was conducted on 60 patients (both sexes, aged 75.90±7.37years) who were recruited in intensive care units at the Special Hospital for Cerebrovascular Diseases "Sveti Sava,” Belgrade. After verification of AIS, patients were followed up in four interval of time: (1) at admission, (2) within 24h after AIS, (3) within 72h after AIS, and (4) 7 days after AIS. At these points of time, blood samples were taken for determination of oxidative stress parameters [index of lipid peroxidation (measured as TBARS), nitric oxide (NO) in the form of nitrite ( $${\text{NO}}_2^-$$ NO 2 - ), superoxide anion radical ( $${\text{O}}_2^ -$$ O 2 - ), hydrogen peroxide (H2O2)], and enzymes of antioxidant defense system [superoxide dismutase (SOD) and catalase (CAT)] using spectrophotometer. Present study provides new insights into redox homeostasis during ischemic stroke which may be of interest in elucidation of molecular mechanisms involved in this life-threatening condition. Particular contribution of obtained results could be examination of connection between redox disruption and clinical outcome in these patients. In that sense, our finding have pointed out that $${\text{O}}_2^ -$$ O 2 - and NO can serve as the most relevant adjuvant biomarkers to monitor disease progression and evaluate therapies. Springer Science+Business Media New York, 2015 Antioxidative system nationallicence Clinical outcome nationallicence Ischemic stroke nationallicence Oxidative stress nationallicence Paspalj Dalibor Institute of Gerontology and Palliative Care, Belgrade, Republic of Serbia aut Nikic Petar Special Hospital for Prevention and Treatment of Cerebrovascular Diseases "Sveti Sava”, Belgrade, Republic of Serbia aut Savic Milan Special Hospital for Prevention and Treatment of Cerebrovascular Diseases "Sveti Sava”, Belgrade, Republic of Serbia aut Djuric Dragan Institute of Medical Physiology "Richard Burian”, School of Medicine, University of Belgrade, Belgrade, Republic of Serbia aut Simanic Igor Specialized Hospital for Rehabilitation and Orthopedic Prosthetics, Belgrade, Serbia aut Zivkovic Vladimir Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica, 34000, Kragujevac, Republic of Serbia aut Jeremic Nevena Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Republic of Serbia aut Srejovic Ivan Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica, 34000, Kragujevac, Republic of Serbia aut Jakovljevic Vladimir Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica, 34000, Kragujevac, Republic of Serbia aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 406/1-2(2015-08-01), 75-81 0300-8177 406:1-2<75 2015 406 11010 https://doi.org/10.1007/s11010-015-2425-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-015-2425-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Paspalj Dalibor Institute of Gerontology and Palliative Care, Belgrade, Republic of Serbia aut NATIONALLICENCE 700 1- Nikic Petar Special Hospital for Prevention and Treatment of Cerebrovascular Diseases "Sveti Sava”, Belgrade, Republic of Serbia aut NATIONALLICENCE 700 1- Savic Milan Special Hospital for Prevention and Treatment of Cerebrovascular Diseases "Sveti Sava”, Belgrade, Republic of Serbia aut NATIONALLICENCE 700 1- Djuric Dragan Institute of Medical Physiology "Richard Burian”, School of Medicine, University of Belgrade, Belgrade, Republic of Serbia aut NATIONALLICENCE 700 1- Simanic Igor Specialized Hospital for Rehabilitation and Orthopedic Prosthetics, Belgrade, Serbia aut NATIONALLICENCE 700 1- Zivkovic Vladimir Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica, 34000, Kragujevac, Republic of Serbia aut NATIONALLICENCE 700 1- Jeremic Nevena Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Republic of Serbia aut NATIONALLICENCE 700 1- Srejovic Ivan Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica, 34000, Kragujevac, Republic of Serbia aut NATIONALLICENCE 700 1- Jakovljevic Vladimir Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica, 34000, Kragujevac, Republic of Serbia aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 406/1-2(2015-08-01), 75-81 0300-8177 406:1-2<75 2015 406 11010