caa a22 4500 606236384 CHVBK 20210128101247.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s11010-014-2277-y doi (NATIONALLICENCE)springer-10.1007/s11010-014-2277-y Serum YKL-40: a potential biomarker for psoriasis or endothelial dysfunction in psoriasis? [Elektronische Daten] [Gamze Erfan, Savas Guzel, Seref Alpsoy, Emine Rifaioglu, Sule Kaya, Volkan Kucukyalcın, Birol Topcu, Mustafa Kulac] Psoriasis is a disease that can contribute to a risk of atherosclerosis. In several studies, impaired endothelial dysfunction (ED) is correlated with psoriasis. Serum YKL-40 is a new inflammatory biomarker of vascular damage, like ED and cardiovascular diseases. The aim of the study was to compare relevance of serum YKL-40 levels in psoriasis patients and healthy subjects according to ED diagnosis and identifiable cardiovascular risk factors. Sixty (31 female, 29 male) patients with plaque psoriasis, and 30 (18 female, 12 male) healthy controls were selected according to whether they had at least one or no identifiable risk factors for cardiovascular disease. All subjects were evaluated ultrasonographically for endothelial function and diagnosed as with or without ED and all groups compared for serum YKL-40 levels. YKL-40 levels of psoriatic patients with ED were higher than healthy controls with ED (P=<0.05). There were no statistical differences in between subjects without ED. YKL-40 levels of patients over age of 40 were higher than younger ones (P<0.05). But in healthy controls, there were no differences. In comparison of cardiovascular risk-positive (RP) patients and RP healthy subjects, YKL-40 levels were higher in RP patients (P=<0.05). The elevation of plasma YKL-40 in psoriasis can be associated not only with inflammation of the disease, but also with ED. YKL-40 can be used as a marker for predicting and preventing cardiovascular diseases in RP psoriatic patients with age above 40. Springer Science+Business Media New York, 2014 Psoriasis nationallicence YKL-40 nationallicence Endothelial dysfunction nationallicence Cardiovascular risk nationallicence Erfan Gamze Department of Dermatology, Faculty of Medicine, Namık Kemal University, Tunca Cad. 100. Yıl Mah., Tekirdag, Turkey aut Guzel Savas Department of Biochemistry, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey aut Alpsoy Seref Department of Cardiology, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey aut Rifaioglu Emine Department of Dermatology, Faculty of Medicine, Namık Kemal University, Tunca Cad. 100. Yıl Mah., Tekirdag, Turkey aut Kaya Sule Department of Dermatology, Faculty of Medicine, Namık Kemal University, Tunca Cad. 100. Yıl Mah., Tekirdag, Turkey aut Kucukyalcın Volkan Department of Biochemistry, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey aut Topcu Birol Department of Biostatistics, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey aut Kulac Mustafa Department of Dermatology, Faculty of Medicine, Namık Kemal University, Tunca Cad. 100. Yıl Mah., Tekirdag, Turkey aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 400/1-2(2015-02-01), 207-212 0300-8177 400:1-2<207 2015 400 11010 https://doi.org/10.1007/s11010-014-2277-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-014-2277-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Erfan Gamze Department of Dermatology, Faculty of Medicine, Namık Kemal University, Tunca Cad. 100. Yıl Mah., Tekirdag, Turkey aut NATIONALLICENCE 700 1- Guzel Savas Department of Biochemistry, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey aut NATIONALLICENCE 700 1- Alpsoy Seref Department of Cardiology, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey aut NATIONALLICENCE 700 1- Rifaioglu Emine Department of Dermatology, Faculty of Medicine, Namık Kemal University, Tunca Cad. 100. Yıl Mah., Tekirdag, Turkey aut NATIONALLICENCE 700 1- Kaya Sule Department of Dermatology, Faculty of Medicine, Namık Kemal University, Tunca Cad. 100. Yıl Mah., Tekirdag, Turkey aut NATIONALLICENCE 700 1- Kucukyalcın Volkan Department of Biochemistry, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey aut NATIONALLICENCE 700 1- Topcu Birol Department of Biostatistics, Faculty of Medicine, Namık Kemal University, Tekirdag, Turkey aut NATIONALLICENCE 700 1- Kulac Mustafa Department of Dermatology, Faculty of Medicine, Namık Kemal University, Tunca Cad. 100. Yıl Mah., Tekirdag, Turkey aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 400/1-2(2015-02-01), 207-212 0300-8177 400:1-2<207 2015 400 11010