caa a22 4500 60623652X CHVBK 20210128101248.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s11010-014-2274-1 doi (NATIONALLICENCE)springer-10.1007/s11010-014-2274-1 Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening [Elektronische Daten] [Jing-Zhi Guan, Wei-Ping Guan, Toyoki Maeda, Xie Guoqing, Wan GuangZhi, Naoki Makino] Lipid peroxidation due to oxidative stress (OS) may play an important role in the pathogenesis of chronic systemic inflammatory diseases such as multiple sclerosis (MS). Telomeres, repeated sequences that cap chromosome ends, undergo shortening with each cycle of cell division, resulting in cellular senescence. Research regarding telomere shortening has provided novel insight into the pathogenesis of various diseases. We hypothesized that OS damage leads to inflammatory reactions, which subsequently shortens the telomere length in MS. We enrolled 59 patients with MS, and age- and gender-matched 60 healthy controls. We divided MS subjects into three groups matched for age and gender according to the severity of disability: relatively benign course (BMS), secondary progressive MS, and primary progressive MS (PPMS). We analyzed the telomere length in peripheral blood mononuclear cells and the 8-iso-PGF2α concentration in urine, a reliable and stable marker of lipid peroxidation in vivo. The data showed significant higher levels of urinary 8-iso-PGF2α in MS subjects than in the controls. The lag-time, which represents the direct measurement of the resistance of low-density lipoprotein to oxidation, was shorter in the PPMS subjects than in the groups. Compared to that observed in the controls, the mean telomere length was significantly shorter in the PPMS group, whereas no significant telomere shortening was found between the controls and other subjects. Our data suggest that a decreased telomere length and enhanced lipid peroxidation reflects the severest stage of MS. Springer Science+Business Media New York, 2014 Oxidative stress nationallicence Telomere nationallicence Multiple sclerosis nationallicence Guan Jing-Zhi The 309th Hospital of Chinese People's Liberation Army, Beijing, China aut Guan Wei-Ping Nanlou Neurology Department, Chinese People's Liberation Army General Hospital, Beijing, China aut Maeda Toyoki Department of Cardiovascular Respiratory, and Geriatric Medicine, Kyushu University Beppu Hospital, Tsurumihara 4546, 874-0838, Beppu, Oita, Japan aut Guoqing Xie The 309th Hospital of Chinese People's Liberation Army, Beijing, China aut GuangZhi Wan The 309th Hospital of Chinese People's Liberation Army, Beijing, China aut Makino Naoki Department of Cardiovascular Respiratory, and Geriatric Medicine, Kyushu University Beppu Hospital, Tsurumihara 4546, 874-0838, Beppu, Oita, Japan aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 400/1-2(2015-02-01), 183-187 0300-8177 400:1-2<183 2015 400 11010 https://doi.org/10.1007/s11010-014-2274-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-014-2274-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Guan Jing-Zhi The 309th Hospital of Chinese People's Liberation Army, Beijing, China aut NATIONALLICENCE 700 1- Guan Wei-Ping Nanlou Neurology Department, Chinese People's Liberation Army General Hospital, Beijing, China aut NATIONALLICENCE 700 1- Maeda Toyoki Department of Cardiovascular Respiratory, and Geriatric Medicine, Kyushu University Beppu Hospital, Tsurumihara 4546, 874-0838, Beppu, Oita, Japan aut NATIONALLICENCE 700 1- Guoqing Xie The 309th Hospital of Chinese People's Liberation Army, Beijing, China aut NATIONALLICENCE 700 1- GuangZhi Wan The 309th Hospital of Chinese People's Liberation Army, Beijing, China aut NATIONALLICENCE 700 1- Makino Naoki Department of Cardiovascular Respiratory, and Geriatric Medicine, Kyushu University Beppu Hospital, Tsurumihara 4546, 874-0838, Beppu, Oita, Japan aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 400/1-2(2015-02-01), 183-187 0300-8177 400:1-2<183 2015 400 11010