caa a22 4500 606236635 CHVBK 20210128101248.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s11010-014-2279-9 doi (NATIONALLICENCE)springer-10.1007/s11010-014-2279-9 Up-regulation of UHRF1 by oncogenic Ras promoted the growth, migration, and metastasis of pancreatic cancer cells [Elektronische Daten] [Lei Cui, Jixiang Chen, Qing Zhang, Xuqing Wang, Jianguo Qu, Jianxin Zhang, Shenchun Dang] Ubiquitin-like with PHD and ring finger domains 1 (UHRF1) has been reported as a marker for the differential diagnosis of pancreatic cancer and chronic pancreatitis. However, the expression pattern and biological functions of UHRF1 in the progression of pancreatic cancer are not fully understood. In this study, it was found that the expression of UHRF1 was significantly up-regulated in pancreatic cancer samples compared to their adjacent normal tissues. Meanwhile, the expression of UHRF1 was inversely correlated with the survival of pancreatic cancer patients. Moreover, in the biological function studies, UHRF1 was shown to promote the growth, migration, and metastasis of pancreatic cancer cells in vitro and in vivo. Mechanistically, the expression of UHRF1 was induced by oncogenic Ras in both pancreatic cancer mouse model and cultured cells. Taken together, our study demonstrated that UHRF1 played an oncogenic role in the progression of pancreatic cancer, and UHRF1 might be a promising target for the treatment of pancreatic cancer. Springer Science+Business Media New York, 2014 UHRF1 nationallicence Pancreatic cancer nationallicence Cell growth and proliferation nationallicence Ras signaling nationallicence Cui Lei General Surgery Department, Affiliated Hospital, Jiangsu University, 212000, Zhenjiang, Jiangsu, China aut Chen Jixiang General Surgery Department, Affiliated Hospital, Jiangsu University, 212000, Zhenjiang, Jiangsu, China aut Zhang Qing General Surgery Department, Affiliated Hospital, Jiangsu University, 212000, Zhenjiang, Jiangsu, China aut Wang Xuqing General Surgery Department, Affiliated Hospital, Jiangsu University, 212000, Zhenjiang, Jiangsu, China aut Qu Jianguo General Surgery Department, Affiliated Hospital, Jiangsu University, 212000, Zhenjiang, Jiangsu, China aut Zhang Jianxin General Surgery Department, Affiliated Hospital, Jiangsu University, 212000, Zhenjiang, Jiangsu, China aut Dang Shenchun General Surgery Department, Affiliated Hospital, Jiangsu University, 212000, Zhenjiang, Jiangsu, China aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 400/1-2(2015-02-01), 223-232 0300-8177 400:1-2<223 2015 400 11010 https://doi.org/10.1007/s11010-014-2279-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-014-2279-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cui Lei General Surgery Department, Affiliated Hospital, Jiangsu University, 212000, Zhenjiang, Jiangsu, China aut NATIONALLICENCE 700 1- Chen Jixiang General Surgery Department, Affiliated Hospital, Jiangsu University, 212000, Zhenjiang, Jiangsu, China aut NATIONALLICENCE 700 1- Zhang Qing General Surgery Department, Affiliated Hospital, Jiangsu University, 212000, Zhenjiang, Jiangsu, China aut NATIONALLICENCE 700 1- Wang Xuqing General Surgery Department, Affiliated Hospital, Jiangsu University, 212000, Zhenjiang, Jiangsu, China aut NATIONALLICENCE 700 1- Qu Jianguo General Surgery Department, Affiliated Hospital, Jiangsu University, 212000, Zhenjiang, Jiangsu, China aut NATIONALLICENCE 700 1- Zhang Jianxin General Surgery Department, Affiliated Hospital, Jiangsu University, 212000, Zhenjiang, Jiangsu, China aut NATIONALLICENCE 700 1- Dang Shenchun General Surgery Department, Affiliated Hospital, Jiangsu University, 212000, Zhenjiang, Jiangsu, China aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 400/1-2(2015-02-01), 223-232 0300-8177 400:1-2<223 2015 400 11010