caa a22 4500 606236767 CHVBK 20210128101249.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s11010-015-2344-z doi (NATIONALLICENCE)springer-10.1007/s11010-015-2344-z miR - 155 promotes the growth of osteosarcoma in a HBP1-dependent mechanism [Elektronische Daten] [Xiaohui Sun, Xiaolin Geng, Jun Zhang, Hongxing Zhao, Ying Liu] Osteosarcoma (OS) is a type of malignant tumor arising from soft-tissues of bone and displays poor prognosis in most cases. However, the molecular mechanism by which OS initiates and progresses is still not completely elucidated. miR-155 has been shown to be overexpressed in OS specimen and cell lines. Our study is intended to explore the role of miR-155 in OS etiology. The data confirmed that miR-155 abundance is higher in OS samples than non-cancerous bone tissue. Inhibition of miR-155 suppressed the proliferation of OS cells and cell cycle progression in vitro, and the growth of OS xenografts in vivo. Wnt pathway was suppressed in OS cells by miR-155 inhibitors. HMG-box transcription factor 1 (HBP1), a strong Wnt pathway suppressor, was found to be a target of miR-155. Restoration of HBP1 abolished the effect of miR-155 on OS cells. Finally, miR-155 levels in OS tissues and serum are both inversely associated with the survival of OS patients. Collectively, miR-155 was identified to be among the list of OS-related oncogenic miRNAs, and HBP1-mediated Wnt signaling is involved with the role of miR-155 in OS progression. Springer Science+Business Media New York, 2015 Osteosarcoma nationallicence miR - 155 nationallicence HBP-1 nationallicence Wnt nationallicence Sun Xiaohui The Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiankang Road, 453100, Weihui, China aut Geng Xiaolin The Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiankang Road, 453100, Weihui, China aut Zhang Jun The Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiankang Road, 453100, Weihui, China aut Zhao Hongxing The Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiankang Road, 453100, Weihui, China aut Liu Ying The Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Xinxiang Medical University, 453100, Weihui, China aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 403/1-2(2015-05-01), 139-147 0300-8177 403:1-2<139 2015 403 11010 https://doi.org/10.1007/s11010-015-2344-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-015-2344-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sun Xiaohui The Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiankang Road, 453100, Weihui, China aut NATIONALLICENCE 700 1- Geng Xiaolin The Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiankang Road, 453100, Weihui, China aut NATIONALLICENCE 700 1- Zhang Jun The Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiankang Road, 453100, Weihui, China aut NATIONALLICENCE 700 1- Zhao Hongxing The Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiankang Road, 453100, Weihui, China aut NATIONALLICENCE 700 1- Liu Ying The Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Xinxiang Medical University, 453100, Weihui, China aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 403/1-2(2015-05-01), 139-147 0300-8177 403:1-2<139 2015 403 11010