caa a22 4500 606236805 CHVBK 20210128101249.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s11010-015-2352-z doi (NATIONALLICENCE)springer-10.1007/s11010-015-2352-z The association between RANKL and Osteoprotegerin gene polymorphisms with breast cancer [Elektronische Daten] [Heba Omar, Olfat Shaker, Yasser Nassar, Samar Marzouk, Mohamed ElMarzouky] Breast cancer is the most common cause of cancer death among women (522,000 deaths in 2012). Imbalance between RANKL and OPG is observed in many cancers, including breast cancer. Consequently, SNPs in the genes of RANKL and OPG may be involved in breast cancer development. This study included 276 subjects. Group I (n=100) healthy females as a control group, group II (n=96) breast cancer patients without bone metastases, and group III (n=80) breast cancer patients with bone metastases. RANKL rs9533156, OPG rs2073618, and OPG rs2073617 SNPs and their serum protein levels were studied for a possible association with breast cancer development. The allele frequency [(OR: 4.832 CI 2.18-10.71, P=0.001) and genotype distribution (P=0.001)] of OPG SNP rs2073618 showed a highly significant difference between breast cancer patients and healthy controls. The allele C is more common in breast cancer patients. The allele frequency [(OR: 0.451 CI 0.232-0.879, P=0.018) and genotype distribution (P=0.003)] of RANKL SNP rs9533156 differed significantly between breast cancer patients and healthy controls. The allele T is more common in breast cancer patients. The allele frequency [(OR: 0.36 CI 0.184-0.705, P=0.002) and genotype distribution (P=0.011)] of OPG SNP rs2073617 differed significantly between breast cancer patients and healthy controls. The allele T is more common in breast cancer patients. The C allele of OPG SNP rs2073618 may be associated with breast cancer development. No association was found between any of the SNPs and the serum protein levels of RANKL and OPG. Springer Science+Business Media New York, 2015 Breast cancer nationallicence RANKL nationallicence OPG nationallicence SNPs nationallicence Bone metastasis nationallicence Omar Heba Medical Biochemistry and Molecular Biology Department, Kasr Al Ainy School of Medicine, Cairo University, Kasr Al Ainy St., El Manial, 11562, Cairo, Egypt aut Shaker Olfat Medical Biochemistry and Molecular Biology Department, Kasr Al Ainy School of Medicine, Cairo University, Kasr Al Ainy St., El Manial, 11562, Cairo, Egypt aut Nassar Yasser Medical Biochemistry and Molecular Biology Department, Kasr Al Ainy School of Medicine, Cairo University, Kasr Al Ainy St., El Manial, 11562, Cairo, Egypt aut Marzouk Samar Medical Biochemistry and Molecular Biology Department, Kasr Al Ainy School of Medicine, Cairo University, Kasr Al Ainy St., El Manial, 11562, Cairo, Egypt aut ElMarzouky Mohamed Department Of General Surgery, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 403/1-2(2015-05-01), 219-229 0300-8177 403:1-2<219 2015 403 11010 https://doi.org/10.1007/s11010-015-2352-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-015-2352-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Omar Heba Medical Biochemistry and Molecular Biology Department, Kasr Al Ainy School of Medicine, Cairo University, Kasr Al Ainy St., El Manial, 11562, Cairo, Egypt aut NATIONALLICENCE 700 1- Shaker Olfat Medical Biochemistry and Molecular Biology Department, Kasr Al Ainy School of Medicine, Cairo University, Kasr Al Ainy St., El Manial, 11562, Cairo, Egypt aut NATIONALLICENCE 700 1- Nassar Yasser Medical Biochemistry and Molecular Biology Department, Kasr Al Ainy School of Medicine, Cairo University, Kasr Al Ainy St., El Manial, 11562, Cairo, Egypt aut NATIONALLICENCE 700 1- Marzouk Samar Medical Biochemistry and Molecular Biology Department, Kasr Al Ainy School of Medicine, Cairo University, Kasr Al Ainy St., El Manial, 11562, Cairo, Egypt aut NATIONALLICENCE 700 1- ElMarzouky Mohamed Department Of General Surgery, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 403/1-2(2015-05-01), 219-229 0300-8177 403:1-2<219 2015 403 11010