caa a22 4500 60623702X CHVBK 20210128101251.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s11010-014-2308-8 doi (NATIONALLICENCE)springer-10.1007/s11010-014-2308-8 CCAAT-enhancer binding protein (C/EBP) β regulates insulin-like growth factor (IGF) 1 expression in porcine liver during prenatal and postnatal development [Elektronische Daten] [Yiting Tang, Kai Xiong, Ming Shen, Yulian Mu, Kui Li, Honglin Liu] IGF1 expression regulation attracts numerous interests because of its important role during mammalian growth and development. Domestic pig can be used as a valuable animal model to investigate human development since they share the high similarity in general physiology and metabolism. In this study, we examined the expression pattern of IGF1 and found it associated with liver C/EBP β expression pattern in porcine liver during embryonic and postnatal development. Both IGF1 and C/EBP β expression in liver maintained at low levels before birth and increased after birth. Correspondingly, C/EBP β demonstrated high binding activity to two sites at IGF1 promoter region in liver after birth. Additionally, IGF1 expression can be activated by C/EBP β overexpression in porcine primary hepatocytes. These results indicated that C/EBP β can activate IGF1 expression after birth by binding to IGF1 promoter. Our study may contribute to a better understanding of mammalian development and bring a novel anti-aging pathway in human. Springer Science+Business Media New York, 2014 C/EBP β nationallicence IGF1 nationallicence Liver nationallicence Transcription factor nationallicence Porcine nationallicence Tang Yiting College of Animal Science and Technology, Nanjing Agricultural University, 210095, Nanjing, People's Republic of China aut Xiong Kai College of Animal Science and Technology, Nanjing Agricultural University, 210095, Nanjing, People's Republic of China aut Shen Ming College of Animal Science and Technology, Nanjing Agricultural University, 210095, Nanjing, People's Republic of China aut Mu Yulian Department of Gene and Cell Engineering, Institute of Animal Science, Chinese Academy of Agricultural Sciences, 100094, Beijing, People's Republic of China aut Li Kui Department of Gene and Cell Engineering, Institute of Animal Science, Chinese Academy of Agricultural Sciences, 100094, Beijing, People's Republic of China aut Liu Honglin College of Animal Science and Technology, Nanjing Agricultural University, 210095, Nanjing, People's Republic of China aut Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 401/1-2(2015-03-01), 209-218 0300-8177 401:1-2<209 2015 401 11010 https://doi.org/10.1007/s11010-014-2308-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11010-014-2308-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tang Yiting College of Animal Science and Technology, Nanjing Agricultural University, 210095, Nanjing, People's Republic of China aut NATIONALLICENCE 700 1- Xiong Kai College of Animal Science and Technology, Nanjing Agricultural University, 210095, Nanjing, People's Republic of China aut NATIONALLICENCE 700 1- Shen Ming College of Animal Science and Technology, Nanjing Agricultural University, 210095, Nanjing, People's Republic of China aut NATIONALLICENCE 700 1- Mu Yulian Department of Gene and Cell Engineering, Institute of Animal Science, Chinese Academy of Agricultural Sciences, 100094, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Li Kui Department of Gene and Cell Engineering, Institute of Animal Science, Chinese Academy of Agricultural Sciences, 100094, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Liu Honglin College of Animal Science and Technology, Nanjing Agricultural University, 210095, Nanjing, People's Republic of China aut NATIONALLICENCE 773 0- Molecular and Cellular Biochemistry Springer US; http://www.springer-ny.com 401/1-2(2015-03-01), 209-218 0300-8177 401:1-2<209 2015 401 11010